Wehinger H, Fürste H O, Imm W, Luthardt T, Sauer M, Slania J, Dilger M
Klin Padiatr. 1978 Jan;190(1):73-82.
42 patients with ALL were treated according to the following protocol: induction with vincristine + prednisone (+/- L-asparaginase), CNS-prophylaxis with cranial irradiation (2400 rads) and intrathecal methotrexate, maintenance for 3 years with 6-MP 50 mg/m2/d p.o. + MTX 75-150 mg/m2/2 wk i.v. X 4, alternating in a cyclic fashion with 6-MP 50 mg/m2/d p.o. + cyclophophshamide 600 mg/m2/2 wk i.v. X 4. The observation time is 24-67 (median 49) months. The actuarial complete remission curve shows 40% continuous complete remissions at 36 months and 30% at 60 months.--The frequency and temporal distribution of typical infectious complications are presented. The incidence of varicella was comparable to that in a southgerman normal control group (5,7% per year). During treatment there were two zoster manifestations per one varicella case, the incidence of zoster being 1 case per 106 patient-months, viz 11,4% per year.
42例急性淋巴细胞白血病患者按以下方案进行治疗：采用长春新碱+泼尼松（±左旋门冬酰胺酶）诱导治疗，采用颅脑照射（2400拉德）和鞘内注射甲氨蝶呤进行中枢神经系统预防，采用6-巯基嘌呤50毫克/平方米/天口服+甲氨蝶呤75 - 150毫克/平方米/每2周静脉注射×4进行维持治疗3年，与6-巯基嘌呤50毫克/平方米/天口服+环磷酰胺600毫克/平方米/每2周静脉注射×4以循环方式交替进行。观察时间为24 - 67（中位值49）个月。精算完全缓解曲线显示36个月时持续完全缓解率为40%，60个月时为30%。——给出了典型感染并发症的发生频率和时间分布。水痘的发病率与南德正常对照组相当（每年5.7%）。治疗期间，每例水痘病例出现2例带状疱疹表现，带状疱疹发病率为每106患者月1例，即每年11.4%。
