Cardaillac C, Rua C, Simon E G, El-Hage W
CHRU de Nantes, hôpital Mère-Enfant, 34, boulevard Jean-Monnet, 44000, Nantes, France.
CHRU de Tours, pôle gynécologie obstétrique-médecine fœtale-reproduction et génétique, 2, boulevard Tonnellé, 37000 Tours, France.
J Gynecol Obstet Biol Reprod (Paris). 2016 Oct;45(8):786-795. doi: 10.1016/j.jgyn.2016.05.002. Epub 2016 Jun 14.
Postpartum depression (PPD) is prevalent (about 10%) with a major impact on the mother and child health. At the hormonal level, poor regulation of oxytocin rate has a key role in depression. Recently, oxytocin has been used on psychiatric therapy, intranasal or intravenously, particularly in mood disorders. But, in obstetrics, this molecule is administered during childbirth. The objective of this study was to determine if intravenous administration of oxytocin could influence thymic state of the mother in the postpartum period.
Literature review, after consultation of Pubmed and Sciencedirect databases, with the following keywords: oxytocin, postpartum depression, pregnancy, social behavior.
The effects of oxytocin in the PPD are part of a multifactorial mechanism (hormonal and social) that influences the hormonal effects of oxytocin. Oxytocin use in therapeutic was able to give conclusive results in psychiatry, the way and the optimal method of administration are not known. PPD is associated with administrated oxytocin during labour. Physiopathology remains unknown.
It is possible that oxytocin administered during childbirth is related with the onset or worsening of the PPD without defining if it's a cause or a consequence.
产后抑郁症（PPD）很常见（约10%），对母婴健康有重大影响。在激素水平上，催产素分泌调节不佳在抑郁症中起关键作用。最近，催产素已用于精神治疗，通过鼻内或静脉注射，特别是在情绪障碍方面。但是，在产科中，这种分子是在分娩期间给药的。本研究的目的是确定静脉注射催产素是否会影响产后母亲的胸腺状态。
在查阅Pubmed和Sciencedirect数据库后进行文献综述，使用以下关键词：催产素、产后抑郁症、妊娠、社会行为。
催产素在产后抑郁症中的作用是多因素机制（激素和社会因素）的一部分，该机制会影响催产素的激素作用。催产素在治疗中的应用在精神病学中能够得出确凿的结果，但其给药方式和最佳方法尚不清楚。产后抑郁症与分娩期间使用催产素有关。其病理生理学仍然未知。
分娩期间使用催产素可能与产后抑郁症的发作或加重有关，但尚不确定它是原因还是结果。
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