Ptácková B, Kopecný J, Zatocil P, Anton M
Cesk Gynekol. 1989 Mar;54(2):106-9.
42 patients with advanced ovarian carcinoma were treated with large doses of cis-DDP by the i.p. route. The toxic effects of platinum were reduced by the i.v. administration of thisulphate. Depending on age and the general condition of the patient, 200-270 mg cis-DDP were administered in one series. Ascites disappeared in 54.7% patients, partial remission of the tumour was achieved in 28.5%, complete histopathological remission confirmed by second look operation in 26.2% and in 21.4% the result was doubtful.
42例晚期卵巢癌患者通过腹腔内途径接受大剂量顺铂治疗。通过静脉注射硫代硫酸盐降低了铂的毒性作用。根据患者的年龄和一般状况，一次疗程给予200 - 270毫克顺铂。54.7%的患者腹水消失，28.5%的患者肿瘤部分缓解，26.2%的患者经二次探查手术证实达到完全组织病理学缓解，21.4%的患者结果存疑。
