Rosa Vinicius, Dubey Nileshkumar, Islam Intekhab, Min Kyung-San, Nör Jacques E
Oral Sciences, Faculty of Dentistry, National University of Singapore, Singapore 119083.
Discipline of Oral and Maxillofacial Surgery, Faculty of Dentistry, National University of Singapore, Singapore 119083.
Stem Cells Int. 2016;2016:5957806. doi: 10.1155/2016/5957806. Epub 2016 May 30.
Stem cells from human exfoliated deciduous teeth (SHED) are highly proliferative pluripotent cells that can be retrieved from primary teeth. Although SHED are isolated from the dental pulp, their differentiation potential is not limited to odontoblasts only. In fact, SHED can differentiate into several cell types including neurons, osteoblasts, adipocytes, and endothelial cells. The high plasticity makes SHED an interesting stem cell model for research in several biomedical areas. This review will discuss key findings about the characterization and differentiation of SHED into odontoblasts, neurons, and hormone secreting cells (e.g., hepatocytes and islet-like cell aggregates). The outcomes of the studies presented here support the multipotency of SHED and their potential to be used for tissue engineering-based therapies.
人脱落乳牙干细胞（SHED）是一类高度增殖的多能细胞，可从乳牙中获取。尽管SHED是从牙髓中分离出来的，但其分化潜能并不局限于仅分化为成牙本质细胞。事实上，SHED可以分化为多种细胞类型，包括神经元、成骨细胞、脂肪细胞和内皮细胞。这种高度的可塑性使SHED成为多个生物医学领域研究中一个有趣的干细胞模型。本综述将讨论关于SHED分化为成牙本质细胞、神经元和激素分泌细胞（如肝细胞和胰岛样细胞聚集体）的特性及分化的关键发现。此处呈现的研究结果支持了SHED的多能性及其在基于组织工程的治疗中应用的潜力。
