Rui Yongjun, Pan Feng, Mi Jingyi
Department of Hand Surgery, Wuxi Number 9 People's Hospital Affiliated to Soochow University, Wuxi, Jiangsu Province 214062, the People's Republic of China.
Anat Rec (Hoboken). 2016 Oct;299(10):1397-401. doi: 10.1002/ar.23384. Epub 2016 Jul 9.
The rat is a suitable model to study human rotator cuff pathology owing to the similarities in morphological anatomy structure. However, few studies have reported the composition muscle fiber types of rotator cuff muscles in the rat. In this study, the myosin heavy chain (MyHC) isoforms were stained by immunofluorescence to show the muscle fiber types composition and distribution in rotator cuff muscles of the rat. It was found that rotator cuff muscles in the rat were of mixed fiber type composition. The majority of rotator cuff fibers labeled positively for MyHCII. Moreover, the rat rotator cuff muscles contained hybrid fibers. So, compared with human rotator cuff muscles composed partly of slow-twitch fibers, the majority of fast-twitch fibers in rat rotator cuff muscles should be considered when the rat model study focus on the pathological process of rotator cuff muscles after injury. Gaining greater insight into muscle fiber types in rotator cuff muscles of the rat may contribute to elucidate the mechanism of pathological change in rotator cuff muscles-related diseases. Anat Rec, 299:1397-1401, 2016. © 2016 Wiley Periodicals, Inc.
由于形态解剖结构相似，大鼠是研究人类肩袖病理的合适模型。然而，很少有研究报道大鼠肩袖肌肉的组成肌纤维类型。在本研究中，通过免疫荧光对肌球蛋白重链（MyHC）同工型进行染色，以显示大鼠肩袖肌肉中肌纤维类型的组成和分布。研究发现，大鼠肩袖肌肉为混合纤维类型组成。大多数肩袖纤维MyHCII染色呈阳性。此外，大鼠肩袖肌肉含有混合纤维。因此，当大鼠模型研究聚焦于肩袖肌肉损伤后的病理过程时，与部分由慢肌纤维组成的人类肩袖肌肉相比，应考虑大鼠肩袖肌肉中的大多数快肌纤维。深入了解大鼠肩袖肌肉中的肌纤维类型可能有助于阐明肩袖肌肉相关疾病的病理变化机制。《解剖学记录》，299:1397 - 1401，2016年。© 2016威利期刊公司。
