Li Dan, Wang Yijie, Wang Linqing, Wang Jie, Wang Pengxin, Wang Kezhou, Lin Li, Liu Dongsheng, Jiang Xianxing, Yang Dongxu
Key Laboratory of Preclinical Study for New Drugs of Gansu Province, Lanzhou University, Lanzhou, 730000, China.
Department of Chemistry, Tsinghua University, Beijing 100084, China.
Chem Commun (Camb). 2016 Jul 26;52(62):9640-3. doi: 10.1039/c6cc02877b.
The first α-sp(2)-carbon of carbonyl compounds attacked catalytic desymmetrization reaction of aziridines is disclosed. A simple in situ generated magnesium catalyst from 3,3'-bromine-8H-BINOL and dibutylmagnesium was employed. It is interesting that the bromine atom on the chiral ligand plays a key role in introducing a high level of enantioselectivities and high reaction efficiency. Both enantiomers of the ring-opening product could be smoothly obtained by using (R)- and (S)-L7.
首次公开了羰基化合物的第一个α-sp(2)-碳进攻氮丙啶的催化去对称化反应。使用了由3,3'-溴-8H-联萘酚和二丁基镁原位生成的简单镁催化剂。有趣的是，手性配体上的溴原子在引入高对映选择性和高反应效率方面起着关键作用。通过使用(R)-和(S)-L7，可以顺利得到开环产物的两种对映体。
