Womersley Jacqueline S, Mpeta Bafokeng, Dimatelis Jacqueline J, Kellaway Lauriston A, Stein Dan J, Russell Vivienne A
Department of Human Biology, Faculty of Health Sciences, University of Cape Town, Anzio Road, Observatory, Cape Town, 7925, South Africa.
Department of Psychiatry and Mental Health, Faculty of Health Sciences, University of Cape Town, Groote Schuur Hospital, Observatory, Cape Town, 7925, South Africa.
Behav Brain Funct. 2016 Jun 17;12(1):18. doi: 10.1186/s12993-016-0102-3.
Developmental stress has been hypothesised to interact with genetic predisposition to increase the risk of developing substance use disorders. Here we have investigated the effects of maternal separation-induced developmental stress using a behavioural proxy of methamphetamine preference in an animal model of attention-deficit/hyperactivity disorder, the spontaneously hypertensive rat, versus Wistar Kyoto and Sprague-Dawley comparator strains.
Analysis of results obtained using a conditioned place preference paradigm revealed a significant strain × stress interaction with maternal separation inducing preference for the methamphetamine-associated compartment in spontaneously hypertensive rats. Maternal separation increased behavioural sensitization to the locomotor-stimulatory effects of methamphetamine in both spontaneously hypertensive and Sprague-Dawley strains but not in Wistar Kyoto rats.
Our findings indicate that developmental stress in a genetic rat model of attention-deficit/hyperactivity disorder may foster a vulnerability to the development of substance use disorders.
有假设认为，发育应激与遗传易感性相互作用会增加患物质使用障碍的风险。在此，我们使用注意力缺陷多动障碍动物模型（自发性高血压大鼠）中甲基苯丙胺偏好的行为指标，对比Wistar Kyoto和Sprague-Dawley对照品系，研究了母体分离诱导的发育应激的影响。
使用条件性位置偏好范式获得的结果分析显示，存在显著的品系×应激相互作用，母体分离诱导自发性高血压大鼠对与甲基苯丙胺相关的隔室产生偏好。母体分离增加了自发性高血压和Sprague-Dawley品系对甲基苯丙胺运动刺激作用的行为敏化，但在Wistar Kyoto大鼠中未出现这种情况。
我们的研究结果表明，注意力缺陷多动障碍基因大鼠模型中的发育应激可能会增加患物质使用障碍的易感性。
