产后使用皮质类固醇与早产儿视网膜病变风险
Postnatal corticosteroids and risk of retinopathy of prematurity.
作者信息
Movsas Tammy Z, Spitzer Alan R, Gewolb Ira H
机构信息
Zietchick Research Institute, Plymouth, Michigan and Midland County Department of Public Health, Midland, Michigan.
MEDNAX Services-Pediatrix Medical Group, Sunrise, Florida.
出版信息
J AAPOS. 2016 Aug;20(4):348-52. doi: 10.1016/j.jaapos.2016.05.008. Epub 2016 Jun 16.
PURPOSE
To investigate the association between postnatal steroids and retinopathy of prematurity (ROP) in neonates born with birth weights at the limit of viability (<500 g).
METHODS
Data from the Pediatrix BabySteps Clinical Warehouse were retrospectively reviewed. The study population consisted of 1,472 neonates with birth weights of <500 g who were discharged alive from 167 NICUs between 1996 and 2013. Statistical significance for unadjusted comparisons between groups was determined using the χ(2) or t test. Logistic regression was used to calculate odds of ROP.
RESULTS
In multivariate analysis, the odds of any ROP for steroid treated infants was 1.6 (95% CI, 1.2-2.2) compared to nontreated infants; the odds of advanced ROP was 1.7 (95% CI, 1.3-2.3).
CONCLUSIONS
In our large study cohort of critically low birth weight infants ROP was more common in neonates exposed to postnatal steroids.
目的
探讨出生体重处于存活临界值（<500g）的新生儿出生后使用类固醇与早产儿视网膜病变（ROP）之间的关联。
方法
对Pediatrix BabySteps临床数据库的数据进行回顾性分析。研究对象为1996年至2013年间出生体重<500g且从167个新生儿重症监护病房（NICU）存活出院的1472例新生儿。采用χ(2)检验或t检验对组间未调整的比较进行统计学显著性分析。使用逻辑回归计算ROP的比值比。
结果
多因素分析显示，与未接受类固醇治疗的婴儿相比，接受类固醇治疗的婴儿发生任何ROP的比值比为1.6（95%CI，1.2 - 2.2）；发生晚期ROP的比值比为1.7（95%CI，1.3 - 2.3）。
结论
在我们这个大型的极低出生体重婴儿研究队列中，出生后使用类固醇的新生儿中ROP更为常见。
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