Wu Fang-Jen, Sheu Shiow-Yunn, Lin Herng-Ching, Chung Shiu-Dong
School of Pharmacy, Taipei Medical University, Taipei, Taiwan.
School of Medical Laboratory Sciences and Biotechnology, Taipei Medical University, Taipei, Taiwan; Sleep Research Center, Taipei Medical University Hospital, Taipei, Taiwan.
Urology. 2016 Sep;95:145-50. doi: 10.1016/j.urology.2016.05.058. Epub 2016 Jun 16.
To examine the relationship between the use of androgen deprivation therapy (ADT) and the subsequent risk of falls in men with prostate cancer (PC) by employing a population-based dataset.
We retrieved the study sample from the Taiwan Longitudinal Health Insurance Database 2005. We included 886 patients with PC who had received ADT as the study group, whereas 862 patients with PC who had not received ADT served as the comparison group. We then individually tracked each study patient for a 3-year period to identify those who subsequently received a diagnosis of a fall. We performed Cox proportional hazard regressions to calculate the hazard ratio (HR) and its corresponding 95% confidence interval (CI) for a fall during the 3-year follow-up period between these 2 groups.
The incidence rates of falls per 1000 person-years were 13.37 (95% CI: 9.1518.88) and 6.44 (95% CI: 3.6110.63), respectively, for patients with PC who received ADT and those who did not receive ADT. Furthermore, the hazard ratio for a fall during the 3-year follow-up period for patients with PC who had received ADT was 1.95 (95% CI: 1.04~3.66, P = .037) compared to those who had not received ADT after censoring sampled patients who died during the 3-year follow-up period and adjusting for age, geographical location, monthly income, urbanization level, hypertension, diabetes, hyperlipidemia, coronary heart disease, Parkinson's disease, epilepsy, stroke, and mental illness.
The present findings suggest that patients with PC who had received ADT had an increased risk of falls.
通过使用基于人群的数据集，研究雄激素剥夺疗法（ADT）的使用与前列腺癌（PC）男性患者随后跌倒风险之间的关系。
我们从2005年台湾纵向健康保险数据库中检索研究样本。我们纳入了886例接受ADT的PC患者作为研究组，而862例未接受ADT的PC患者作为对照组。然后我们对每位研究患者进行了为期3年的单独跟踪，以确定那些随后被诊断为跌倒的患者。我们进行了Cox比例风险回归，以计算这两组在3年随访期内跌倒的风险比（HR）及其相应的95%置信区间（CI）。
接受ADT的PC患者和未接受ADT的PC患者每1000人年的跌倒发生率分别为13.37（95%CI：9.1518.88）和6.44（95%CI：3.6110.63）。此外，在对3年随访期内死亡的抽样患者进行审查并调整年龄、地理位置、月收入、城市化水平、高血压、糖尿病、高脂血症、冠心病、帕金森病、癫痫、中风和精神疾病后，接受ADT的PC患者在3年随访期内跌倒的风险比为1.95（95%CI：1.04~3.66，P = 0.037），而未接受ADT的患者为1。
目前的研究结果表明，接受ADT的PC患者跌倒风险增加。
