Inserm U932, Institut Curie, ANR-10-IDEX-0001-02 PSL* and ANR-11-LABX-0043, Paris, France.
Immunol Rev. 2016 Jul;272(1):39-51. doi: 10.1111/imr.12429.
Antigen presentation refers to the ability of cells to show MHC-associated determinants to T lymphocytes, leading to their activation. MHC class II molecules mainly present peptide-derived antigens that are internalized by endocytosis in antigen-presenting cells (APCs). Here, we describe how the interface between cellular membranes and the cytoskeleton regulates the various steps that lead to the presentation of exogenous antigens on MHC class II molecules in the two main types of APCs: dendritic cells (DCs) and B lymphocytes. This includes antigen uptake, processing, APC migration, and APC-T cell interactions. We further discuss how the interaction between APC-specific molecules and cytoskeleton elements allows the coordination of antigen presentation and cell migration in time and space.
抗原呈递是指细胞将 MHC 相关决定簇展示给 T 淋巴细胞，从而导致其激活的能力。MHC II 类分子主要呈递通过内吞作用在抗原提呈细胞 (APC) 内摄取的肽衍生抗原。在这里，我们描述了细胞膜和细胞骨架之间的界面如何调节导致 MHC II 类分子在外源抗原呈递中的各种步骤，这在两种主要的 APC 中：树突状细胞 (DC) 和 B 淋巴细胞。这包括抗原摄取、加工、APC 迁移和 APC-T 细胞相互作用。我们还进一步讨论了 APC 特异性分子与细胞骨架元件之间的相互作用如何允许在时间和空间上协调抗原呈递和细胞迁移。
