Chen Yu, Wang Chunxue, Liang Huazheng, Chen Hongyan, Bi Yanchao, Sun Haixin, Shi Qingli, Deng Yongmei, Li Jia, Wang Yongjun, Zhang Yumei
a Department of Neurology, Beijing Tiantan Hospital , Capital Medical University , Beijing , China.
b China National Clinical Research Center for Neurological Diseases , Beijing , China.
Neurol Res. 2016 Jun;38(6):510-7. doi: 10.1080/01616412.2016.1177929.
The aim of the study was to investigate the difference of resting-state default-mode network (DMN) between patients with leukoaraiosis (LA)-associated subcortical vascular cognitive impairment (SVCI) and control subjects, and to provide functional imaging evidence of SVCI.
All subjects (n = 58) were divided into two groups based on their clinical diagnosis: a LA-associated SVCI group (n = 31, 14 males) and a control group (n = 27, 14 males). Demographic information and resting-state functional MRI (rs-fMRI) data were obtained. These subjects were assessed using the Hamilton Anxiety Depression Scale, Clinical Dementia Rating, Mini Mental State Exam, and Montreal Cognitive Assessment. Experimental data and confounding factors were described with a General Liner Model. Independent components of fMRI data were analyzed with an fMRI toolbox.
The active areas involved in DMN of LA-associated SVCI group were similar to those of the control group. However, several active areas of LA-associated SVCI group, especially the left anterior cingulate cortex and the right parahippocampal gyrus, showed significantly lower blood oxygen level-dependent (BOLD) signals compared with the control group (p ≤ 0.05); whereas the left caudate nucleus (p = 0.015), the right frontal lobe (p = 0.004), and the superior temporal gyrus/inferior parietal gyrus (p = 0.001) exhibited significantly higher BOLD signals compared with the control group.
The present study provides neuroimaging evidence for the recognition of LA-associated SVCI. Moreover, the differences in the functional alterations of the resting-state DMN might be a distinguishing feature between SVCI and amnestic mild cognitive impairment patients.
本研究旨在探讨伴有白质疏松（LA）的皮质下血管性认知障碍（SVCI）患者与对照组在静息态默认模式网络（DMN）上的差异，为SVCI提供功能影像学证据。
所有受试者（n = 58）根据临床诊断分为两组：LA相关的SVCI组（n = 31，男性14例）和对照组（n = 27，男性14例）。获取人口统计学信息和静息态功能磁共振成像（rs-fMRI）数据。使用汉密尔顿焦虑抑郁量表、临床痴呆评定量表、简易精神状态检查和蒙特利尔认知评估对这些受试者进行评估。用一般线性模型描述实验数据和混杂因素。使用功能磁共振成像工具箱分析功能磁共振成像数据的独立成分。
LA相关的SVCI组DMN涉及的激活区域与对照组相似。然而，LA相关的SVCI组的几个激活区域，尤其是左侧前扣带回皮质和右侧海马旁回，与对照组相比，血氧水平依赖（BOLD）信号显著降低（p≤0.05）；而左侧尾状核（p = 0.015）、右侧额叶（p = 0.004）和颞上回/顶下小叶（p = 0.001）与对照组相比，BOLD信号显著升高。
本研究为LA相关的SVCI的识别提供了神经影像学证据。此外，静息态DMN功能改变的差异可能是SVCI与遗忘型轻度认知障碍患者之间的一个区别特征。
