Cox T A
Department of Ophthalmology, University of British Columbia, Vancouver, Canada.
Invest Ophthalmol Vis Sci. 1989 Jun;30(6):1127-31.
Relative afferent pupillary defects were simulated in normal individuals by performing the alternating light test while dimming the light in front of one eye with neutral density filters. Pupillary responses were elicited using a binocular photostimulator and recorded using a binocular television pupillometer. In five subjects, four spatial variables of the pupillary response--contraction amplitude, minimum size, final size, and redilatation amplitude--were measured and compared. Contraction amplitude was found to be the best indicator of small pupil defects. In eight other subjects, the contraction amplitude elicited by using filters from 0.3 to 3.0 log units in density was plotted. Amplitude of consensual responses increased as direct responses decreased, and initial constrictions were visible in many subjects at the 1.8 log unit level. The best method for detecting relative afferent pupillary defects using the alternating light test is to compare contraction amplitudes, looking for consensual responses that are greater than direct responses.
通过在进行交替光试验的同时用中性密度滤光片使一只眼前的光线变暗，在正常个体中模拟相对性传入性瞳孔障碍。使用双目光刺激器引发瞳孔反应，并使用双目电视瞳孔计进行记录。在五名受试者中，测量并比较了瞳孔反应的四个空间变量——收缩幅度、最小尺寸、最终尺寸和再扩张幅度。发现收缩幅度是小瞳孔缺陷的最佳指标。在另外八名受试者中，绘制了使用密度为0.3至3.0对数单位的滤光片所引发的收缩幅度。随着直接反应的降低，同感性反应的幅度增加，并且在许多受试者中，在1.8对数单位水平可见初始收缩。使用交替光试验检测相对性传入性瞳孔障碍的最佳方法是比较收缩幅度，寻找大于直接反应的同感性反应。
