Liu Ji-Chen, Guo Kai, Lu Hao, Li Meng-Hao, Lai Wen-Yan, Guo Zhi-Gang
Huiqiao Medical Center, Nanfang Hospital, Southern Medical University, Guangzhou510515, China. E-mail:
Nan Fang Yi Ke Da Xue Xue Bao. 2016 Jun;36(6):875-9.
To study the association of red blood cell distribution width (RDW) and lipoprotein-associated phospholipase A2 (LP-PLA2) with the degree of coronary artery stenosis in patients with coronary artery disease (CAD) and the value of RDW combined with LP-PLA2 detection in accurate evaluation of coronary artery stenosis.
A total of 224 patients including 119 non-CAD cases and 105 CAD cases admitted in our hospital between June, 2013 and June, 2014 were enrolled in this study. The patients' baseline clinical data were collected and venous blood samples were obtained for detecting WBC, RDW-CV and LP-PLA2. The Gensini score of the CAD patients was calculated based on coronary angiographic findings.
Compared with the non-CAD patients, CAD patients had significantly higher RDW-CV (P=0.009) and LP-PLA2 (P=0.004) levels. The CAD patients with high Gensini scores had also significantly higher RDW-CV (P=0.001) and LP-PLA2 (P<0.001) levels than those with low scores; RDW-CV and LP-PLA2 were significantly correlated with the Gensini score, and the area under curve of their combined detection was 0.931.
Combination of RDW and LP-PLA2 can improve the diagnostic accuracy of the degree of coronary artery stenosis in patients with CAD.
研究红细胞分布宽度（RDW）和脂蛋白相关磷脂酶A2（LP-PLA2）与冠心病（CAD）患者冠状动脉狭窄程度的相关性，以及RDW联合LP-PLA2检测在准确评估冠状动脉狭窄中的价值。
选取2013年6月至2014年6月我院收治的224例患者，其中非CAD患者119例，CAD患者105例。收集患者的基线临床资料，并采集静脉血样检测白细胞、RDW-CV和LP-PLA2。根据冠状动脉造影结果计算CAD患者的Gensini评分。
与非CAD患者相比，CAD患者的RDW-CV（P = 0.009）和LP-PLA2（P = 0.004）水平显著更高。Gensini评分高的CAD患者的RDW-CV（P = 0.001）和LP-PLA2（P < 0.001）水平也显著高于评分低的患者；RDW-CV和LP-PLA2与Gensini评分显著相关，其联合检测的曲线下面积为0.931。
RDW与LP-PLA2联合检测可提高CAD患者冠状动脉狭窄程度的诊断准确性。
