Ding Lin, Wang Dan, Zhou Miaomiao, Du Lei, Xu Jie, Xue Changhu, Wang Yuming
College of Food Science and Engineering, Ocean University of China.
J Oleo Sci. 2016 Jul 1;65(7):593-602. doi: 10.5650/jos.ess16005. Epub 2016 Jun 16.
Recent studies have shown that EPA enriched PLs have beneficial effects on lipid metabolism. Our previous study has demonstrated that the anti-obesity and hypolipidemic effects of EPA-PL were superior to DHA-PL. In the present study, we comparatively evaluated the effects of EPA-enriched phosphatidylcholine (EPA-PC) and EPA-enriched phosphatidylserine (EPA-PS) on lipid metabolism in mice. Both 2% dietary EPA-PC and EPA-PS significantly improved serum and hepatic lipid levels in mice. The HDL-c level in mice on EPA-PC diet was significantly higher than the other two groups. The level of DHA in hepatic TG and PL were significantly increased in both EPA-PC and EPA-PS fed groups (98.3 and 117.8%, respectively; p < 0.05). Notably, the proportion of DHA in EPA-PS group was significantly higher than the EPA-PC group. EPA-PC and EPA-PS suppressed hepatic SREBP-1c mediated lipogenesis and activated PPARα mediated fatty acid β-oxidation in the liver. These data are the first to indicate that EPA-PS has beneficial effects on lipid metabolism.
最近的研究表明，富含二十碳五烯酸（EPA）的磷脂对脂质代谢具有有益作用。我们之前的研究表明，EPA磷脂的抗肥胖和降血脂作用优于DHA磷脂。在本研究中，我们比较评估了富含EPA的磷脂酰胆碱（EPA-PC）和富含EPA的磷脂酰丝氨酸（EPA-PS）对小鼠脂质代谢的影响。饮食中2%的EPA-PC和EPA-PS均显著改善了小鼠的血清和肝脏脂质水平。食用EPA-PC饮食的小鼠的高密度脂蛋白胆固醇（HDL-c）水平显著高于其他两组。在喂食EPA-PC和EPA-PS的两组中，肝脏甘油三酯（TG）和磷脂中DHA的水平均显著升高（分别为98.3%和117.8%；p<0.05）。值得注意的是，EPA-PS组中DHA的比例显著高于EPA-PC组。EPA-PC和EPA-PS抑制肝脏中由固醇调节元件结合蛋白-1c（SREBP-1c）介导的脂肪生成，并激活肝脏中由过氧化物酶体增殖物激活受体α（PPARα）介导的脂肪酸β-氧化。这些数据首次表明EPA-PS对脂质代谢具有有益作用。
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