College of Food Science and Engineering, Ocean University of China, Qingdao, 266003, Shandong, China.
Centre for Nutrition and Food Sciences, Queensland Alliance for Agriculture and Food Innovation, The University of Queensland, Brisbane, QLD, 4072, Australia.
Lipids Health Dis. 2020 May 25;19(1):104. doi: 10.1186/s12944-020-01253-3.
Glycerophospholipids were the main components of cerebral cortex lipids, and there was a close association between lipid homeostasis and human health. It has been reported that dietary DHA-enriched phosphatidylcholine (DHA-PC) and phosphatidylserine (DHA-PS) could improve brain function. However, it was unclear that whether supplementation of DHA-PC and DHA-PS could change lipid profiles in the brain of dementia animals.
SAMP8 mice was fed with different diet patterns for 2 months, including high-fat diet and low-fat diet. After intervention with DHA-PC and DHA-PS for another 2 months, the lipid profile in cerebral cortex was determined by lipidomics in dementia mice.
High-fat diet could significantly decrease the levels of DHA-containing PS/pPE, DPA-containing PS, and AA-containing PE, which might exhibit the potential of lipid biomarkers for the prevention and diagnosis of AD. Notably, DHA-PC and DHA-PS remarkably recovered the lipid homeostasis in dementia mice. These might provide a potential novel therapy strategy and direction of dietary intervention for patients with cognitive decline.
DHA-PC and DHA-PS could recover the content of brain DHA-containing PS and pPE in SAMP8 mice fed with high-fat diet.
甘油磷脂是大脑皮质脂质的主要成分，脂质平衡与人类健康密切相关。有报道称，富含二十二碳六烯酸的磷脂酰胆碱（DHA-PC）和磷脂酰丝氨酸（DHA-PS）的饮食可以改善大脑功能。然而，补充 DHA-PC 和 DHA-PS 是否可以改变痴呆动物大脑中的脂质谱尚不清楚。
采用不同的饮食模式（高脂肪饮食和低脂肪饮食）喂养 SAMP8 小鼠 2 个月。用 DHA-PC 和 DHA-PS 干预 2 个月后，用脂质组学方法检测痴呆小鼠大脑皮质的脂质谱。
高脂肪饮食可显著降低 DHA 含量 PS/pPE、DPA 含量 PS 和 AA 含量 PE，可能作为 AD 预防和诊断的潜在脂质生物标志物。值得注意的是，DHA-PC 和 DHA-PS 可显著恢复痴呆小鼠的脂质平衡。这可能为认知功能下降的患者提供一种潜在的新型治疗策略和饮食干预方向。
高脂肪饮食喂养的 SAMP8 小鼠中，DHA-PC 和 DHA-PS 可恢复大脑 DHA 含量 PS 和 pPE 的含量。
