Centre for Digestive Diseases, Division of Hepatology, Karolinska University Hospital, Stockholm, Sweden; Department of Medicine, Huddinge, Karolinska Institutet, Stockholm, Sweden.
Centre for Digestive Diseases, Division of Hepatology, Karolinska University Hospital, Stockholm, Sweden; Department of Medicine, Huddinge, Karolinska Institutet, Stockholm, Sweden.
J Hepatol. 2016 Aug;65(2):363-8. doi: 10.1016/j.jhep.2016.03.019. Epub 2016 Jun 16.
BACKGROUND & AIMS: The increased prevalence of overweight has been suggested to contribute to the worldwide increase in liver diseases. We investigated if body mass index (BMI) in late adolescence predicts development of severe liver disease later in life.
We performed a cohort study using data from 44,248 men (18-20years) conscribed to military service in Sweden between 1969 and 1970. Outcome data were collected from national registers to identify any diagnosis of severe liver disease (i.e., diagnosis of decompensated liver disease, cirrhosis or death in liver disease) until the end of 2009. A Cox regression model was applied using BMI as independent variable. The model was adjusted for use of alcohol, use of narcotics, smoking, high blood pressure and cognitive ability at time of conscription.
During a follow-up period of a mean of 37.8years, 393 men were diagnosed with severe liver disease (mean time to diagnosis 24.7years). BMI (Hazard ratio [HR]=1.05 for each unit increase in BMI, 95% confidence interval [CI]: 1.01-1.09, p=0.008) and overweight (HR=1.64 for BMI 25-30 compared to BMI 18.5-22.5, 95% CI: 1.16-2.32, p=0.006) were associated with an increased risk of development of severe liver disease.
Being overweight in late adolescence is a significant predictor of severe liver disease later in life in men.
We investigated close to 45,000 Swedish men in their late teens enlisted for conscription in 1969-1970. After almost 40years of follow-up, we found that being overweight was a risk factor for developing severe liver disease, independent of established risk factors such as alcohol consumption.
超重患病率的增加被认为是导致全球范围内肝病增加的原因之一。本研究旨在探究青春期后期的体重指数（BMI）是否可以预测成年后严重肝脏疾病的发生。
我们进行了一项队列研究，共纳入了 44248 名 18-20 岁在瑞典服兵役的男性士兵（1969 年至 1970 年）。通过国家登记册收集结局数据，以确定任何严重肝脏疾病的诊断（即代偿性肝脏疾病、肝硬化或肝脏疾病死亡的诊断），直到 2009 年底。使用 Cox 回归模型，将 BMI 作为自变量。该模型调整了入伍时的酒精使用、麻醉品使用、吸烟、高血压和认知能力等因素。
在平均 37.8 年的随访期间，有 393 名男性被诊断为严重肝脏疾病（平均诊断时间为 24.7 年）。BMI（风险比[HR]=1.05，每增加一个单位 BMI，95%置信区间[CI]：1.01-1.09，p=0.008）和超重（HR=1.64，BMI 为 25-30 与 BMI 为 18.5-22.5 相比，95%CI：1.16-2.32，p=0.006）与严重肝脏疾病发展的风险增加相关。
青春期后期超重是成年后严重肝脏疾病的重要预测因素。
我们研究了接近 45000 名在 1969 年至 1970 年入伍的瑞典青少年男性。经过近 40 年的随访，我们发现超重是发生严重肝脏疾病的一个危险因素，与酒精摄入等既定危险因素无关。
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