Sarpe Paduraru Ana-Maria, Dodul Cristina, Vlase Emil-Andrei, Onișor Cristian, Niculet Elena, Ciobotaru Octavian Catalin, Drima Eduard Polea
Faculty of Medicine and Pharmacy, "Dunarea de Jos" University of Galati, 35 Al. I. Cuza Street, 800008 Galati, Romania.
"Sf. Apostol Andrei" Emergency County Clinical Hospital Galati, 177 Brailei Street, 800578 Galati, Romania.
Life (Basel). 2024 Jul 12;14(7):873. doi: 10.3390/life14070873.
The purpose of this study is to examine healthcare usage, morbidities, and alcohol consumption monitoring in patients before a diagnosis of mental manifestations to assist in the early identification of individuals at risk. Biological markers of alcoholism are separated into two groups: those biological variables that highlight with great confidence and validate the presence of a predisposition to alcoholism, also called trait markers, or those that highlight alcohol consumption, called markers of alcoholism ("status markers"). Biomarkers are the true "gold standard" for the diagnosis of alcoholism. They are valuable for tracking evolution and progress during biological and psychological therapy and for highlighting relapse. This review compiles the existing data from research on healthcare utilization, comorbidities, and alcohol consumption monitoring in patients before a diagnosis of mental manifestations to aid in the early identification of individuals at risk. This documentary study took place over three to four months by searching for terms on the Science Direct platform, PubMed, Web of Science, and Google Scholar such as alcoholism, alcohol use disorders, alcohol abuse, and biomarkers. Studies reporting on the development, characteristics, and utilization of blood biomarkers for alcohol consumption were included in the search. The initial search included a number of 11.019 articles that contained the keywords biomarkers and alcohol. Finally, a total of 50 research articles were considered. I am involved in clinical studies, meta-analyses, reviews, and case studies regarding alcohol consumption detection, as well as potential alcohol markers.
本研究的目的是检查在诊断出精神症状之前患者的医疗保健使用情况、发病率和酒精消费监测情况,以协助早期识别有风险的个体。酒精中毒的生物标志物分为两组:一类是能够高度可靠地突出显示并证实存在酒精中毒易感性的生物变量,也称为特质标志物;另一类是突出显示酒精消费情况的标志物,称为酒精中毒标志物(“状态标志物”)。生物标志物是诊断酒精中毒的真正“金标准”。它们对于追踪生物和心理治疗期间的进展情况以及突出显示复发情况很有价值。这篇综述汇编了在诊断出精神症状之前患者的医疗保健利用、合并症和酒精消费监测方面的现有研究数据,以帮助早期识别有风险的个体。这项文献研究通过在科学Direct平台、PubMed、科学网和谷歌学术上搜索诸如酒精中毒、酒精使用障碍、酒精滥用和生物标志物等术语,历时三到四个月。搜索中纳入了报告血液中酒精消费生物标志物的开发、特征和利用情况的研究。初步搜索得到了11019篇包含关键词生物标志物和酒精的文章。最后,共考虑了50篇研究文章。我参与了有关酒精消费检测以及潜在酒精标志物的临床研究、荟萃分析、综述和案例研究。