Barry Jeremy M, Sakkaki Sophie, Barriere Sylvain J, Patterson Katelin P, Lenck-Santini Pierre Pascal, Scott Rod C, Baram Tallie Z, Holmes Gregory L
Department of Neurological Sciences, University of Vermont College of Medicine, Burlington, Vermont, United States.
Department of Neurological Sciences, University of Vermont College of Medicine, Burlington, Vermont, United States.
EBioMedicine. 2016 May;7:175-90. doi: 10.1016/j.ebiom.2016.03.039. Epub 2016 Apr 6.
The coordination of dynamic neural activity within and between neural networks is believed to underlie normal cognitive processes. Conversely, cognitive deficits that occur following neurological insults may result from network discoordination. We hypothesized that cognitive outcome following febrile status epilepticus (FSE) depends on network efficacy within and between fields CA1 and CA3 to dynamically organize cell activity by theta phase. Control and FSE rats were trained to forage or perform an active avoidance spatial task. FSE rats were sorted by those that were able to reach task criterion (FSE-L) and those that could not (FSE-NL). FSE-NL CA1 place cells did not exhibit phase preference in either context and exhibited poor cross-theta interaction between CA1 and CA3. FSE-L and control CA1 place cells exhibited phase preference at peak theta that shifted during active avoidance to the same static phase preference observed in CA3. Temporal coordination of neuronal activity by theta phase may therefore explain variability in cognitive outcome following neurological insults in early development.
神经网络内部以及神经网络之间动态神经活动的协调被认为是正常认知过程的基础。相反，神经损伤后出现的认知缺陷可能是由网络失调导致的。我们假设，热性惊厥持续状态（FSE）后的认知结果取决于CA1和CA3区域内部以及它们之间的网络效能，即通过θ相位动态组织细胞活动。对对照大鼠和FSE大鼠进行觅食或主动回避空间任务训练。将FSE大鼠分为能够达到任务标准的（FSE-L）和不能达到任务标准的（FSE-NL）。FSE-NL组的CA1位置细胞在任何一种环境中都未表现出相位偏好，并且在CA1和CA3之间表现出较差的跨θ相互作用。FSE-L组和对照组的CA1位置细胞在θ波峰值时表现出相位偏好，在主动回避过程中会转移到与CA3中观察到的相同的静态相位偏好。因此，θ相位对神经元活动的时间协调可能解释了早期发育中神经损伤后认知结果的变异性。
