Gnanaraj Jerome, Balakrishnan Shobana, Umar Zarish, Antonarakis Emmanuel S, Pavlovich Christian P, Wright Scott M, Khaliq Waseem
Department of Medicine, Johns Hopkins Bayview Medical Center, School of Medicine, Johns Hopkins University, 5200 Eastern Avenue, MFL Bldg, West Tower 6th Floor, Baltimore, MD, 21224, USA.
Department of General Surgery, Royal Lancaster Infirmary, Lancaster, UK.
Med Oncol. 2016 Jul;33(7):81. doi: 10.1007/s12032-016-0796-y. Epub 2016 Jun 20.
The objectives of the study were to explore the context and reasons for medical hospitalizations among prostate cancer survivors and to study their relationship with obesity and the type of prostate cancer treatment. A retrospective review of medical records was performed at an academic institution for male patients aged 40 years and older who were diagnosed and/or treated for prostate cancer 2 years prior to the study's observation period from January 2008 to December 2010. Unpaired t test, ANOVA, and Chi-square tests were used to compare patients' characteristics, admission types, and medical comorbidities by body mass index (BMI) and prostate cancer treatment. Mean age for the study population was 76 years (SD = 9.2). Two hundred and forty-five prostate cancer survivors were stratified into two groups: non-obese (BMI < 30 kg/m(2)) and obese (BMI ≥ 30 kg/m(2)). The study population's characteristics analyzed by BMI were similar including Gleason score, presence of metastatic disease and genitourinary-related side effects. Only 13 % of admissions were for complaints related to their genitourinary system. Neither the specific treatment that the patients had received for their prostate cancer, nor obesity was associated with the reasons for their medical admission. Survivorship after having a diagnosis of prostate cancer is often lengthy, and these men are at risk of being hospitalized, as they get older. From this inquiry, it has become clear that neither body mass index nor prior therapy is associated with specific admission characteristics, and only a minority of such admissions was directly related to prostate cancer or the genitourinary tract.
该研究的目的是探讨前列腺癌幸存者住院治疗的背景和原因,并研究其与肥胖及前列腺癌治疗类型的关系。在一所学术机构对年龄40岁及以上的男性患者进行了病历回顾性研究,这些患者在2008年1月至2010年12月研究观察期前2年被诊断和/或接受过前列腺癌治疗。采用非配对t检验、方差分析和卡方检验,按体重指数(BMI)和前列腺癌治疗方式比较患者的特征、入院类型和合并症。研究人群的平均年龄为76岁(标准差=9.2)。245名前列腺癌幸存者被分为两组:非肥胖组(BMI<30kg/m²)和肥胖组(BMI≥30kg/m²)。按BMI分析的研究人群特征相似,包括 Gleason评分、转移性疾病的存在情况和泌尿生殖系统相关副作用。只有13%的入院是因与泌尿生殖系统相关的主诉。患者接受的前列腺癌具体治疗以及肥胖均与入院原因无关。前列腺癌确诊后的生存期通常较长,随着年龄增长,这些男性有住院风险。从这项调查可以清楚地看出,体重指数和既往治疗均与特定的入院特征无关,且此类入院中只有少数与前列腺癌或泌尿生殖道直接相关。