Costa P, Galtier M, Laurelli J M, Nivard G, Louis J F, Favier M, Hansel S, Navratil H, Grasset D
Service d'Urologie-Andrologie, Centre Hospitalier Gaston Doumergue, Nîmes.
J Urol (Paris). 1989;95(1):41-4.
Acute epididymitis is a common infection in the young sexually active adult. Etiologically, the organisms most frequently found are Chlamydia trachomatis, Neisseria gonorrhea and gram negative bacilli. Pefloxacin is a novel quinolone whose antibacterial spectrum and bactericidal activity allow it to be considered for use in the treatment of orchitis and epididymitis Prior to clinical study the authors investigated the degree of epididymal diffusion of Pefloxacin. Ten subjects underwent extraction of an epididymal sample by direct access to the epididymis through a transverse scrotal incision under peridural anesthesia. Three days before surgery, Pefloxacin was administrated at the rate of 400 mg every 12 hours by the oral route. On the day of the operation, the subject receive a 400 mg infusion over one hour, 2 hours before epididymal biopsy. Blood specimens were also extracted. Pefloxacin assays were performed by HPLC following a method derived from that of Montay. The trough concentration of Pefloxacin inhibiting 90% of sensitive strains (MIC 90) is less than or equal to 2 micro-g/ml. The majority of sensitive organisms have minimum bactericidal concentrations equal to twice the MIC 90. The epididymal concentrations that the authors measured are situated at values of 8.15 to 21.80 miro-g/g tissue (mean 13.44). These data allow the use of Pefloxacin to be considered an option in the treatment of epididymitis.
急性附睾炎是年轻性活跃成年人中常见的感染性疾病。从病因学角度来看，最常发现的病原体是沙眼衣原体、淋病奈瑟菌和革兰氏阴性杆菌。培氟沙星是一种新型喹诺酮类药物，其抗菌谱和杀菌活性使其可被考虑用于治疗睾丸炎和附睾炎。在进行临床研究之前，作者研究了培氟沙星在附睾中的扩散程度。10名受试者在硬膜外麻醉下通过阴囊横切口直接进入附睾提取附睾样本。手术前3天，口服培氟沙星，剂量为每12小时400毫克。手术当天，在附睾活检前2小时，受试者在1小时内输注400毫克培氟沙星。同时也采集了血液样本。采用源自蒙泰方法的高效液相色谱法进行培氟沙星检测。抑制90%敏感菌株的培氟沙星最低抑菌浓度（MIC90）小于或等于2微克/毫升。大多数敏感菌的最低杀菌浓度等于MIC90的两倍。作者测得的附睾浓度为8.15至21.80微克/克组织（平均13.44）。这些数据表明培氟沙星可被视为治疗附睾炎的一种选择。
