Waterfield Thomas, Dyer Emma, Wilson Kathryn, Boyle Robert J
Paediatric Emergency Department, Royal Belfast Hospital for Sick Children, Belfast, UK.
Department Of Paediatrics, Royal Free Hospital, London, UK.
Arch Dis Child Educ Pract Ed. 2016 Oct;101(5):246-51. doi: 10.1136/archdischild-2015-309887. Epub 2016 Jun 20.
Mast cell tryptase (tryptase) is an enzyme produced almost exclusively by mast cells that is easy to measure using a widely available test. In this article we discuss the physiology of the mast cell and how that relates to IgE-mediated anaphylaxis and mastocytosis. We also describe the technical aspects of testing tryptase and the reported normal ranges in health. Finally we explore the diagnostic performance of serum mast cell tryptase measurements, when used to confirm anaphylaxis, estimate future anaphylaxis risk and in diagnosing/monitoring leukaemia.
肥大细胞类胰蛋白酶（类胰蛋白酶）是一种几乎仅由肥大细胞产生的酶，使用一种广泛可用的检测方法很容易进行测量。在本文中，我们讨论了肥大细胞的生理学及其与IgE介导的过敏反应和肥大细胞增多症的关系。我们还描述了检测类胰蛋白酶的技术方面以及所报道的健康人群的正常范围。最后，我们探讨了血清肥大细胞类胰蛋白酶检测在用于确认过敏反应、评估未来过敏反应风险以及诊断/监测白血病时的诊断性能。
