基于金的药物封装在铁蛋白纳米笼内：作为负载Auoxo3的蛋白质潜在抗癌剂的X射线结构和生物学评价。
Gold-based drug encapsulation within a ferritin nanocage: X-ray structure and biological evaluation as a potential anticancer agent of the Auoxo3-loaded protein.
作者信息
Ferraro Giarita, Monti Daria Maria, Amoresano Angela, Pontillo Nicola, Petruk Ganna, Pane Francesca, Cinellu Maria Agostina, Merlino Antonello
机构信息
Department of Chemical Sciences, University of Naples Federico II, Complesso Universitario di Monte Sant'Angelo, Via Cintia, I-80126, Napoli, Italy.
Department of Chemistry and Pharmacy, University of Sassari, Via Vienna 2, 07100 Sassari, Italy and CIRCC, Consorzio Interuniversitario Reattività Chimica e Catalisi, Università di Bari, Via Celso Ulpiani 27, 70126 Bari, Italy.
出版信息
Chem Commun (Camb). 2016 Jul 21;52(61):9518-21. doi: 10.1039/c6cc02516a.
Auoxo3, a cytotoxic gold(iii) compound, was encapsulated within a ferritin nanocage. Inductively coupled plasma mass spectrometry, circular dichroism, UV-Vis absorption spectroscopy and X-ray crystallography confirm the potential-drug encapsulation. The structure shows that naked Au(i) ions bind to the side chains of Cys48, His49, His114, His114 and Cys126, Cys126, His132, His147. The gold-encapsulated nanocarrier has a cytotoxic effect on different aggressive human cancer cells, whereas it is significantly less cytotoxic for non-tumorigenic cells.
细胞毒性金（III）化合物Auoxo3被包裹在铁蛋白纳米笼中。电感耦合等离子体质谱、圆二色性、紫外可见吸收光谱和X射线晶体学证实了潜在药物的包封。结构表明，裸露的金（I）离子与半胱氨酸48、组氨酸49、组氨酸114、组氨酸114以及半胱氨酸126、半胱氨酸126、组氨酸132、组氨酸147的侧链结合。包金纳米载体对不同侵袭性人类癌细胞具有细胞毒性作用，而对非致瘤细胞的细胞毒性则明显较小。
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