Department of Chemical Sciences, University of Naples Federico II, Complesso Universitario di Monte Sant'Angelo, Via Cintia, I-80126, Napoli, Italy.
Dalton Trans. 2017 Nov 14;46(44):15354-15362. doi: 10.1039/c7dt02370g.
Two anticancer gold(iii) compounds, Au2phen and Auoxo4, were encapsulated within a ferritin nanocage. The gold-compound loaded proteins were characterized by UV-Vis spectroscopy, inductively coupled plasma mass spectrometry and circular dichroism. X-ray crystallography shows that the compounds degrade upon encapsulation and gold(i) ions bind Ft within the cage, close to the side chains of Cys126. The gold-encapsulated nanocarriers are cytotoxic to human cancer cells. Au(i)-loaded Ft, obtained upon the encapsulation of Au2phen within the cage, induces oxidative stress activation, which finally leads to apoptosis in MCF-7 cells.
两种抗癌金（III）化合物，Au2phen 和 Auoxo4，被包裹在一个铁蛋白纳米笼内。通过紫外可见光谱、电感耦合等离子体质谱和圆二色性对负载有金化合物的蛋白质进行了表征。X 射线晶体学表明，化合物在包裹过程中降解，金（I）离子结合 Ft 位于笼内，靠近 Cys126 的侧链。金包裹的纳米载体对人癌细胞具有细胞毒性。Au2phen 被包裹在笼内形成的 Au(i)-loaded Ft 诱导氧化应激激活，最终导致 MCF-7 细胞凋亡。
