一项基于家庭的运动计划对低至中度风险骨髓增生异常综合征患者身体能力和疲劳的影响——一项试点研究。

Effects of a home-based exercise program on physical capacity and fatigue in patients with low to intermediate risk myelodysplastic syndrome-a pilot study.

作者信息

Schuler Markus K, Hentschel Leopold, Göbel Julia, Balaian Ekaterina, Hornemann Beate, Hoffmann Julia, Kramer Michael, Kasten Philip, Bornhäuser Martin, Ehninger Gerhard, Platzbecker Uwe

机构信息

Department of Internal Medicine I, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany; University Cancer Center, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany; Clinic for Internal Medicine II, HELIOS Hospital Emil von Behring, Walterhöferstraße 11, 14165 Berlin, Germany.

University Cancer Center, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.

出版信息

Leuk Res. 2016 Aug;47:128-35. doi: 10.1016/j.leukres.2016.05.022. Epub 2016 May 27.

DOI:10.1016/j.leukres.2016.05.022

PMID:27326698

Abstract

INTRODUCTION

Fatigue is a frequent and disabling symptom in myelodysplastic syndromes (MDS). There is evidence for the benefit of exercise on fatigue in haematological malignancies, but clinical trials targeting patients with MDS do not exist.

METHODS

A prospective, non-randomized feasibility trial was conducted to assess the safety and efficacy of a home-based exercise intervention in patients with MDS. Exercise schedule contained endurance or strength training in daily turns over 12 weeks. Outcome measures included 6-min walking distance (6-MWD), an ergometer check, strength measurement of lower limb, abdomen and back, quality of life and fatigue.

RESULTS

Twenty-one patients (13 male, 8 female) were included. Median age was 66 years (range 29-87). Fifteen patients (71%) continued the program till week 12 (T1), of whom eleven patients met criteria for program completion. There were no adverse events reported due to the intervention. 6-MWD significantly improved from 580m at T0 to 645m at T1 (p<0.05). Fatigue scores did not significantly change over time (MFI: 12.8 vs. 12.3 vs. 11.9; QLQ-C30 fatigue scale: 48.2 vs. 46.7 vs. 47.4).

CONCLUSION

These data provide evidence that an unsupervised outpatient exercise program is feasible and can improve physical capacity. Randomized, controlled studies implementing these interventions are warranted.

摘要

引言

疲劳是骨髓增生异常综合征（MDS）中常见且致残的症状。有证据表明运动对血液系统恶性肿瘤患者的疲劳有益，但针对MDS患者的临床试验尚不存在。

方法

进行了一项前瞻性、非随机的可行性试验，以评估居家运动干预对MDS患者的安全性和有效性。运动计划包括在12周内每日交替进行耐力或力量训练。结局指标包括6分钟步行距离（6-MWD）、测力计检查、下肢、腹部和背部力量测量、生活质量和疲劳程度。

结果

纳入21例患者（13例男性，8例女性）。中位年龄为66岁（范围29 - 87岁）。15例患者（71%）持续参与该计划至第12周（T1），其中11例患者符合计划完成标准。未报告因干预导致的不良事件。6-MWD从T0时的580米显著提高至T1时的645米（p<0.05）。疲劳评分随时间未显著变化（多维疲劳量表：12.8对12.3对11.9；欧洲癌症研究与治疗组织生活质量核心问卷疲劳量表：48.2对46.7对47.4）。