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备择假设：单侧还是双侧？

The alternative hypothesis: one-sided or two-sided?

作者信息

Peace K E

机构信息

Parke-Davis Research Division, Warner-Lambert Company, Ann Arbor, MI 48105.

出版信息

J Clin Epidemiol. 1989;42(5):473-6. doi: 10.1016/0895-4356(89)90137-6.

DOI:10.1016/0895-4356(89)90137-6
PMID:2732775
Abstract

The appropriateness of a one-sided alternative hypothesis rather than the more conservative, boiler-plate, two-sided hypothesis is discussed and examples provided. It is concluded that confirmatory efficacy clinical trials of pharmaceutical compounds should always be viewed within the one-sided alternative hypothesis testing framework.

摘要

讨论了单侧备择假设相对于更为保守、千篇一律的双侧假设的适用性，并给出了示例。得出的结论是，药物化合物的确证性疗效临床试验应始终在单侧备择假设检验框架内进行考量。

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