Check J H, Choe J K, Summers-Chase D
Clin Exp Obstet Gynecol. 2016;43(3):332-3.
To corroborate or refute a previous study suggesting that intrauterine infusion of granulocyte colony stimulating factor (G-CSF) could significantly improve endometrial thickness into more fertile levels when the endometrial thickness was ≤ five mm.
Three women whose endometrial thickness never exceeded five mm on the in vitro fertilization-embryo transfer (IVF-ET) cycle or subsequent attempted frozen ETs using graduated estradiol had intrauterine infusion of G-CSF to the estradiol regimen.
Not one of the three women improved the endometrial thickness beyond five mm and none conceived on the G-CSF cycle. One woman had a subsequent pregnancy following a frozen ET with only a four-mm thickness with no infusion of G-CSF.
These data do not confirm the efficacy of intrauterine infusion of G-CSF for poor endometrial thickness. Perhaps only certain cases will respond. A larger series could take time to accumulate since other studies have shown that only 0.3% of women with ≤ five mm endometrial thickness in the late proliferative phase during an IVF-ET cycle will not improve the endometrial thickness > five mm using graduated estradiol protocols.
证实或反驳之前的一项研究，该研究表明，当子宫内膜厚度≤5毫米时，宫腔内注入粒细胞集落刺激因子（G-CSF）可显著将子宫内膜厚度提高到更有利于受孕的水平。
三名女性在体外受精-胚胎移植（IVF-ET）周期或随后使用递增雌二醇进行的冷冻胚胎移植尝试中，子宫内膜厚度从未超过5毫米，她们在雌二醇治疗方案基础上进行了宫腔内G-CSF注入。
三名女性中没有一人的子宫内膜厚度增加到超过5毫米，且在G-CSF治疗周期中无人受孕。一名女性在随后的冷冻胚胎移植后怀孕，当时子宫内膜厚度仅4毫米，未进行G-CSF注入。
这些数据不能证实宫腔内注入G-CSF对子宫内膜薄的有效性。或许只有某些病例会有反应。由于其他研究表明，在IVF-ET周期的增殖晚期，子宫内膜厚度≤5毫米的女性中，只有0.3%使用递增雌二醇方案时子宫内膜厚度不会增加到>5毫米，因此可能需要时间来积累更大规模的病例系列。
