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1
Clinical Question: Does Medical Evidence Support Routine Oronasopharyngeal Suction at Delivery?临床问题:医学证据是否支持分娩时常规进行口鼻咽部吸引?
J Okla State Med Assoc. 2016 Apr-May;109(4-5):140-2.
2
Effect of oronasopharyngeal suction on arterial oxygen saturation in normal, term infants delivered vaginally: a prospective randomised controlled trial.
J Obstet Gynaecol. 2014 Jul;34(5):400-2. doi: 10.3109/01443615.2014.897312. Epub 2014 Jun 9.
3
Oronasopharyngeal suction at birth: effects on arterial oxygen saturation.
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The pros and cons of suctioning at the perineum (intrapartum) and post-delivery with and without meconium.会阴吸引术(分娩期)及产后有或没有胎粪情况下吸引术的利弊。
Semin Fetal Neonatal Med. 2008 Dec;13(6):375-82. doi: 10.1016/j.siny.2008.04.001. Epub 2008 May 13.
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Oronasopharyngeal suction versus no suction in normal and term infants delivered by elective cesarean section: a prospective randomized controlled trial.
Gynecol Obstet Invest. 2006;61(1):9-14. doi: 10.1159/000087604. Epub 2005 Aug 19.
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Effects of pharyngeal suction on the arterial oxygen saturation and heart rate in healthy newborns delivered by elective cesarean section.选择性剖宫产分娩的健康新生儿中咽部吸引对动脉血氧饱和度和心率的影响。
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Lancet. 2004;364(9434):597-602. doi: 10.1016/S0140-6736(04)16852-9.
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Endotracheal Suction for Nonvigorous Neonates Born through Meconium Stained Amniotic Fluid: A Randomized Controlled Trial.对胎粪污染羊水出生的无活力新生儿进行气管内吸引:一项随机对照试验
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Meconium-stained amniotic fluid and respiratory complications: impact of selective tracheal suction.胎粪污染羊水与呼吸并发症:选择性气管吸引的影响
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本文引用的文献

1
Routine oro/nasopharyngeal suction versus no suction at birth.出生时常规口/鼻咽吸引与不进行吸引的比较。
Cochrane Database Syst Rev. 2017 Apr 18;4(4):CD010332. doi: 10.1002/14651858.CD010332.pub2.
2
Effect of oronasopharyngeal suction on arterial oxygen saturation in normal, term infants delivered vaginally: a prospective randomised controlled trial.
J Obstet Gynaecol. 2014 Jul;34(5):400-2. doi: 10.3109/01443615.2014.897312. Epub 2014 Jun 9.
3
Oronasopharyngeal suction versus wiping of the mouth and nose at birth: a randomised equivalency trial.出生时经口鼻咽吸引与擦拭的比较:一项随机等效性试验。
Lancet. 2013 Jul 27;382(9889):326-30. doi: 10.1016/S0140-6736(13)60775-8. Epub 2013 Jun 3.
4
Part 15: neonatal resuscitation: 2010 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care.第15部分:新生儿复苏:2010年美国心脏协会心肺复苏及心血管急救指南
Circulation. 2010 Nov 2;122(18 Suppl 3):S909-19. doi: 10.1161/CIRCULATIONAHA.110.971119.
5
Part 11: Neonatal resuscitation: 2010 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science with Treatment Recommendations.第11部分:新生儿复苏:2010年国际心肺复苏与心血管急救科学及治疗建议共识。
Resuscitation. 2010 Oct;81 Suppl 1:e260-87. doi: 10.1016/j.resuscitation.2010.08.029.
6
The pros and cons of suctioning at the perineum (intrapartum) and post-delivery with and without meconium.会阴吸引术(分娩期)及产后有或没有胎粪情况下吸引术的利弊。
Semin Fetal Neonatal Med. 2008 Dec;13(6):375-82. doi: 10.1016/j.siny.2008.04.001. Epub 2008 May 13.
7
Oropharyngeal and nasopharyngeal suctioning of meconium-stained neonates before delivery of their shoulders: multicentre, randomised controlled trial.在新生儿肩部娩出前对胎粪污染的新生儿进行口咽和鼻咽吸引:多中心随机对照试验。
Lancet. 2004;364(9434):597-602. doi: 10.1016/S0140-6736(04)16852-9.

临床问题:医学证据是否支持分娩时常规进行口鼻咽部吸引?

Clinical Question: Does Medical Evidence Support Routine Oronasopharyngeal Suction at Delivery?

作者信息

Evans M Blake, Po William D

出版信息

J Okla State Med Assoc. 2016 Apr-May;109(4-5):140-2.

PMID:27328554
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4918762/
Abstract

Oronasopharyngeal suction (ONPS) is regularly performed in neonates at delivery in many hospitals across the country today. Although ONPS is a technique that has essentially become habitual for most obstetricians, its theorized usefulness to help promote expeditious lung aeration after delivery by removal of amniotic fluid, meconium, mucus and blood that may otherwise be aspirated by the newborn, is currently not recommended. ONPS can cause vagal stimulation-induced bradycardia and thus hypercapnea, iatrogenic infection due to mucous membrane injury, and development of subsequent neonatal brain injury due to changes in cerebral blood flow regulation, particularly in premature infants. Multiple studies that have been performed comparing routine use of ONPS to no intervention controls indicate that newborns receiving ONPS took a longer time to achieve normal oxygen saturations, caused apneic episodes, and caused disturbances in heart rate (mainly bradycardia) compared to the control groups. Although the ONPS groups revealed no significantly different APGAR scores at 1 and 5 minutes, the ONPS groups took longer than the control group to reach an arterial oxygen saturation greater than or equal to 92% in the first minutes of life. Currently, Neonatal Resuscitation Program guidelines discourage the use of or meconium-stained amniotic fluid and in the absence of obvious obstruction. Furthermore, this manuscript highlights various literature sources revealing that the routine use of ONPS at the time of delivery can cause more harm than good, if any good at all.

摘要

如今,在全国许多医院,口咽鼻咽吸引术(ONPS)在新生儿分娩时经常被实施。尽管对大多数产科医生来说,ONPS基本上已成为一种习惯性操作,但目前不建议使用该技术,其理论上有助于在分娩后通过清除羊水、胎粪、黏液和血液来促进肺部快速通气,否则这些物质可能会被新生儿吸入。ONPS可导致迷走神经刺激引起的心动过缓,进而导致高碳酸血症,因黏膜损伤引起医源性感染,以及由于脑血流调节变化导致随后的新生儿脑损伤,尤其是早产儿。多项将ONPS常规使用与无干预对照组进行比较的研究表明,与对照组相比,接受ONPS的新生儿达到正常血氧饱和度所需时间更长,会引发呼吸暂停发作,并导致心率紊乱(主要是心动过缓)。尽管ONPS组在1分钟和5分钟时的阿氏评分没有显著差异,但在出生后的头几分钟内,ONPS组达到动脉血氧饱和度大于或等于92%所需的时间比对照组更长。目前,新生儿复苏计划指南不鼓励在羊水未被胎粪污染且无明显梗阻的情况下使用ONPS。此外,本手稿强调了各种文献资料,表明在分娩时常规使用ONPS可能弊大于利,甚至可能根本没有益处。