Ogino Keiki, Obase Yasushi, Ito Tatsuo, Fujimura Masaki, Eguchi Eri, Kubo Masayuki, Nagaoka Kenjiro, Nakamura Hiroyuki
a Department of Public Health , Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences , Okayama , Japan.
b Division of Respiratory Diseases, Department of Medicine , Kawasaki Medical School , Okayama , Japan.
Free Radic Res. 2016;50(11):1165-1172. doi: 10.1080/10715762.2016.1202407. Epub 2016 Aug 25.
The relationship between serum arginase I and serum l-arginine or fractional exhaled nitric oxide (FENO) was evaluated cross-sectionally in asthmatic patients. No sex difference was observed in the serum mean levels of arginase I and l-arginine or FENO. Arginase I and FENO were higher in patients 60 or younger years than in those over 60 years. Asthmatic patients were divided into three groups: no steroid therapy, inhalation steroid therapy, and oral steroid therapy. Arginase I, FENO and high-sensitivity-C-reactive protein (hs-CRP) were significantly lower in the inhalation steroid therapy group than in the no steroid therapy group. Correlations were observed between arginase I and FENO, l-arginine, hs-CRP, WBC, and age, and also between FENO and IgE, WBC, and age. A logistic regression analysis revealed the positive association of arginase I with FENO, and the negative association of l-arginine. FENO was positively associated with arginase I and IgE. These results indicated that serum arginase I might influence serum levels of l-arginine and FENO, and that IgE might influence FENO in asthmatic patients.
我们对哮喘患者进行了横断面研究，以评估血清精氨酸酶I与血清L-精氨酸或呼出气一氧化氮分数（FENO）之间的关系。精氨酸酶I、L-精氨酸或FENO的血清平均水平未观察到性别差异。60岁及以下患者的精氨酸酶I和FENO水平高于60岁以上患者。哮喘患者被分为三组：未接受类固醇治疗组、吸入类固醇治疗组和口服类固醇治疗组。吸入类固醇治疗组的精氨酸酶I、FENO和高敏C反应蛋白（hs-CRP）显著低于未接受类固醇治疗组。观察到精氨酸酶I与FENO、L-精氨酸、hs-CRP、白细胞和年龄之间存在相关性，FENO与IgE、白细胞和年龄之间也存在相关性。逻辑回归分析显示精氨酸酶I与FENO呈正相关，L-精氨酸呈负相关。FENO与精氨酸酶I和IgE呈正相关。这些结果表明，血清精氨酸酶I可能影响哮喘患者血清L-精氨酸和FENO水平，IgE可能影响FENO水平。
