Nichols V N, Fraley J K, Evans K D, Nichols B L
U.S. Department of Agriculture, Children's Nutrition Research Center, Houston, TX 77030.
J Pediatr Gastroenterol Nutr. 1989 Jan;8(1):51-7. doi: 10.1097/00005176-198901000-00011.
To determine the frequency with which acquired monosaccharide intolerance (AMI) occurs in infants less than 3 months of age, we performed a prospective descriptive study of infants admitted to the hospital for diarrhea. We searched for differences between the characteristics and causes of AMI in these infants and those of a cohort of similar-aged infants admitted with acute diarrhea (AD). Five hundred fifty-five infants less than 3 months of age admitted with diarrhea were enrolled. Nine percent of those infants had AMI, 40% had other forms of chronic diarrhea, and 51% had AD. The mean age at hospital admission was 32 days for the infants with AMI and 44 days for the infants with AD. The mean weight loss of AMI infants was 0.3 g/day since birth, and the mean weight gain was 14.3 g/day for AD infants. The mean dehydration by difference in weights at admission and 48 h postadmission was 5% for AMI and 3% for AD infants. Bacterial and viral causes of the diarrhea were similar. At admission to the hospital, infants in whom AMI subsequently developed were younger, more malnourished, had more prolonged diarrhea, and were more dehydrated than the AD infants. Malnutrition stands out as a significant antecedent factor that contributes to the development of AMI.
为确定3个月龄以下婴儿获得性单糖不耐受（AMI）的发生频率，我们对因腹泻入院的婴儿进行了一项前瞻性描述性研究。我们探究了这些婴儿与一组因急性腹泻（AD）入院的同龄婴儿在AMI特征和病因方面的差异。纳入了555名3个月龄以下因腹泻入院的婴儿。这些婴儿中9%患有AMI，40%患有其他形式的慢性腹泻，51%患有AD。AMI婴儿入院时的平均年龄为32天，AD婴儿为44天。AMI婴儿自出生以来的平均体重减轻为0.3克/天，AD婴儿的平均体重增加为14.3克/天。根据入院时体重与入院后48小时体重差异计算，AMI婴儿的平均脱水率为5%，AD婴儿为3%。腹泻的细菌和病毒病因相似。在入院时，随后发生AMI的婴儿比AD婴儿更年幼、营养不良更严重、腹泻持续时间更长且脱水更严重。营养不良是导致AMI发生的一个重要前期因素。
