Jiang Lin, Wang Wenchao, Li Guoli, Sun Canlin, Ren Zhenqin, Sheng Haihui, Gao Hengjun, Wang Chaofu, Yu Hong
Department of Anesthesiology, Taizhou People's Hospital, Taizhou, Jiangsu, China.
Department of Pathology, Yangzhou University School of Medicine, Yangzhou, Jiangsu, China.
Cancer Chemother Pharmacol. 2016 Aug;78(2):333-9. doi: 10.1007/s00280-016-3066-y. Epub 2016 Jun 21.
Long noncoding RNAs (lncRNAs) play critical roles in diverse biological processes such as tumorigenesis and metastasis. Taurine upregulated gene 1 (TUG1) is a cancer-related lncRNA that is associated with chromatin-modifying complexes and plays an important role in gene regulation. In this study, we determined the expression patterns of TUG1 in esophageal squamous cell carcinoma (ESCC) and evaluated its clinical significance.
The expression level of TUG1 was examined in 218 pairs of ESCC and adjacent non-cancerous tissues by using quantitative real-time polymerase chain reaction. The relationship between TUG1 expression and clinical features and prognosis was statistically analyzed.
The expression level of TUG1 was significantly upregulated in ESCC tissues compared with paired adjacent normal tissues. High TUG1 expression was significantly correlated with chemotherapy resistance. Survival analysis showed that patients with high TUG1 expression had poor prognosis, especially for cases with well and moderate differentiation, ulcerative type, smaller size, and chemotherapy-sensitive tumors.
Our findings suggest that elevated TUG1 expression is related to chemotherapy resistance and may help predict a poor prognostic outcome of ESCC. TUG1 may provide a potential therapeutic target for ESCC.
长链非编码RNA（lncRNA）在肿瘤发生和转移等多种生物学过程中发挥关键作用。牛磺酸上调基因1（TUG1）是一种与癌症相关的lncRNA，与染色质修饰复合物相关，并在基因调控中起重要作用。在本研究中，我们确定了TUG1在食管鳞状细胞癌（ESCC）中的表达模式，并评估了其临床意义。
采用定量实时聚合酶链反应检测218对ESCC组织和癌旁非癌组织中TUG1的表达水平。对TUG1表达与临床特征及预后的关系进行统计学分析。
与配对的癌旁正常组织相比，ESCC组织中TUG1的表达水平显著上调。TUG1高表达与化疗耐药显著相关。生存分析表明，TUG1高表达的患者预后较差，尤其是高分化和中分化、溃疡型、较小尺寸以及化疗敏感肿瘤的患者。
我们的研究结果表明，TUG1表达升高与化疗耐药有关，可能有助于预测ESCC的不良预后。TUG1可能为ESCC提供一个潜在的治疗靶点。
