Chen Nai-Feng, Lo Chien-Ming, Liu Tzu-Ling, Cheng Shih-Kuen
Institute of Cognitive Neuroscience, National Central University, Taiwan.
Institute of Cognitive Neuroscience, National Central University, Taiwan.
Neuroimage. 2016 Oct 1;139:462-469. doi: 10.1016/j.neuroimage.2016.06.032. Epub 2016 Jun 18.
This study employed transcranial direct current stimulation (tDCS) to examine whether the left posterior parietal cortex (LPPC) is causally involved in episodic memory retrieval. Thirty-six participants were assigned to the anodal or the cathodal stimulation group with the block-randomization method and engaged in three source memory tests on three separate days. During the test phase, the participants received anodal or cathodal stimulation over the LPPC scalp region in one visit, sham over the LPPC in another visit, and anodal or cathodal stimulation over the right primary motor cortex (M1) scalp region in the other visit. The results showed that source memory accuracy, but not old/new recognition performance, decreased significantly when participants in the cathodal group received stimulation over the LPPC scalp region in comparison to the other two stimulation conditions. No such effect was found in the anodal group. These findings provide evidence for the causal relationship between the LPPC and episodic memory retrieval.
本研究采用经颅直流电刺激（tDCS）来检验左后顶叶皮层（LPPC）是否因果性地参与情景记忆提取。36名参与者通过区组随机化方法被分配到阳极刺激组或阴极刺激组，并在三个不同的日子进行三项来源记忆测试。在测试阶段，参与者在一次就诊时接受LPPC头皮区域的阳极或阴极刺激，在另一次就诊时接受LPPC的假刺激，在另一次就诊时接受右初级运动皮层（M1）头皮区域的阳极或阴极刺激。结果显示，与其他两种刺激条件相比，当阴极组参与者在LPPC头皮区域接受刺激时，来源记忆准确性显著下降，但旧/新识别表现未下降。在阳极组未发现这种效应。这些发现为LPPC与情景记忆提取之间的因果关系提供了证据。
