Weinstock M A, Colditz G A, Willett W C, Stampfer M J, Bronstein B R, Mihm M C, Speizer F E
Department of Medicine (Dermatology), Veterans Administration Medical Center, Davis Park, Providence, RI 02908.
J Natl Cancer Inst. 1989 Jun 21;81(12):948-52. doi: 10.1093/jnci/81.12.948.
We examined the relationship between self-reported mole counts and cutaneous melanoma with respect to anatomic site in 110 case and 231 control female nurses. Counts of moles on the lower leg were better predictors of melanoma risk than were counts of moles on the arm. The relative risk for the highest quintile of lower leg mole counts versus no lower leg moles was 4.2. Mole counts at each site (arm, thigh, and lower leg) were associated with risk of melanoma of the trunk and lower leg, but none were associated with the risk of melanoma of the upper extremity. The absence of direct site-specificity suggests that mole counts primarily indicate systemic melanoma risk, rather than direct risk from the moles themselves.
我们在110名患皮肤黑色素瘤的女性护士病例和231名对照女性护士中，研究了自我报告的痣数量与皮肤黑色素瘤之间在解剖部位方面的关系。小腿上痣的数量比手臂上痣的数量更能预测黑色素瘤风险。小腿痣数量最高五分位数组与小腿无痣组相比，相对风险为4.2。每个部位（手臂、大腿和小腿）痣的数量与躯干和小腿黑色素瘤风险相关，但均与上肢黑色素瘤风险无关。缺乏直接的部位特异性表明，痣的数量主要指示全身性黑色素瘤风险，而非痣本身的直接风险。
