慢性髓性白血病和红白血病中氨基酸萘基酰胺酶的同工酶

Isozymes of amino acid naphthylamidase in chronic meyloid leukaemia and erythroleukaemia.

作者信息

Sinna G A, Lenner P, Lundgren E, Roos G

出版信息

Scand J Haematol. 1978 Feb;20(2):153-8. doi: 10.1111/j.1600-0609.1978.tb02440.x.

DOI:10.1111/j.1600-0609.1978.tb02440.x

Abstract

Isozymes of amino acid naphthylamidase were investigated in 11 patients with chronic myeloid leukaemia (CML) and 1 patient with erythroleukaemia. Two isozymes were found in all cases (isozymes A and C) which also occur in normal granulocytes. An isozyme with intermediate mobility appeared in all the patients in two main forms (isozymes BF and BS), which both differed from the isozyme B found in normal granulocytes. This may therefore support the diagnosis. In 3 patients a shift occurred between isozymes BF and BS, the possible significance of which is discussed.

摘要

对11例慢性粒细胞白血病（CML）患者和1例红白血病患者的氨基酸萘基酰胺酶同工酶进行了研究。在所有病例中均发现两种同工酶（同工酶A和C），它们也存在于正常粒细胞中。一种具有中间迁移率的同工酶在所有患者中以两种主要形式出现（同工酶BF和BS），这两种形式均与正常粒细胞中发现的同工酶B不同。因此，这可能有助于诊断。在3例患者中，同工酶BF和BS之间发生了转变，并对其可能的意义进行了讨论。