Hisadome M, Terasawa M, Goto K, Kawazoe Y, Okumoto T
Research Laboratories, Yoshitomi Pharmaceutical Industries, Ltd., Fukuoka, Japan.
Jpn J Pharmacol. 1989 Feb;49(2):275-84. doi: 10.1254/jjp.49.275.
Phagocytosis of yeast particles by mouse peritoneal macrophages or rat peritoneal polymorphonuclear leukocytes was enhanced by traxanox sodium in vitro. Traxanox sodium (30 and 100 mg/kg, p.o.) enhanced phagocytosis of yeast particles by leukocytes and macrophages in vivo or ex vivo. On the other hand, prednisolone, isoproterenol and theophylline inhibited phagocytosis by leukocytes and macrophages under the same conditions. Traxanox sodium (30 mg/kg, p.o.) prevented the suppression of phagocytosis by the above drugs. Combined with theophylline, isoproterenol synergistically inhibited phagocytosis by leukocytes in vivo. Traxanox sodium (100 mg/kg, p.o.) administered alone had no influence on carbon clearance in normal mice. However, traxanox sodium (1-30 mg/kg, p.o.) prevented the suppression of carbon clearance by the treatment with carrageenan, but not by the treatment with ethyl palmitate. These results suggest that traxanox sodium stimulates the phagocytic activity of leukocytes or macrophages and prevents the drug-induced suppression of the phagocytic activity of these cells.
曲安西龙钠在体外可增强小鼠腹腔巨噬细胞或大鼠腹腔多形核白细胞对酵母颗粒的吞噬作用。曲安西龙钠（30和100毫克/千克，口服）在体内或体外均可增强白细胞和巨噬细胞对酵母颗粒的吞噬作用。另一方面，在相同条件下，泼尼松龙、异丙肾上腺素和茶碱会抑制白细胞和巨噬细胞的吞噬作用。曲安西龙钠（30毫克/千克，口服）可防止上述药物对吞噬作用的抑制。与茶碱联合使用时，异丙肾上腺素在体内可协同抑制白细胞的吞噬作用。单独给予曲安西龙钠（100毫克/千克，口服）对正常小鼠的碳清除率没有影响。然而，曲安西龙钠（1 - 30毫克/千克，口服）可防止卡拉胶处理对碳清除率的抑制，但不能防止棕榈酸乙酯处理对碳清除率的抑制。这些结果表明，曲安西龙钠可刺激白细胞或巨噬细胞的吞噬活性，并防止药物诱导的这些细胞吞噬活性的抑制。
