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没食子酸月桂酯对云母表面有序磷脂薄膜润湿性的影响。

Effect of Lauryl Gallate on Wetting Properties of Organized Thin Phospholipid Films on Mica.

作者信息

Jurak Małgorzata

机构信息

Department of Physical Chemistry-Interfacial Phenomena, Faculty of Chemistry, Maria Curie-Skłodowska University , Maria Curie-Skłodowska Sq. 3, 20031 Lublin, Poland.

出版信息

J Phys Chem B. 2016 Jul 14;120(27):6657-66. doi: 10.1021/acs.jpcb.6b02434. Epub 2016 Jun 30.

Abstract

To characterize surfaces of phospholipid/lauryl gallate monolayers deposited on mica there were applied numerous methods such as measurements of advancing and receding contact angles and optical profilometry, as well as atomic force microscopy. As a result, there was no found correlation between contact angles (and their hysteresis) or surface roughness. Hence, most monolayer topographical changes at the Ångstrom level accompanied changes in surface chemistry which resulted in the hysteresis of contact angle on thin films. The obtained results indicate that stability and permeability of the binary films are determined by the composition and stoichiometry of the mixed monolayers. These results can be helpful for insight into lauryl gallate behavior in living systems, i.e., in membrane antioxidant protection and pharmacological activities.

摘要

为了表征沉积在云母上的磷脂/没食子酸月桂酯单层膜的表面,应用了多种方法,如测量前进和后退接触角、光学轮廓测量法以及原子力显微镜。结果发现,接触角(及其滞后现象)与表面粗糙度之间没有相关性。因此,在埃尺度上,大多数单层膜的形貌变化伴随着表面化学性质的变化,这导致了薄膜上接触角的滞后现象。所得结果表明,二元膜的稳定性和渗透性由混合单层膜的组成和化学计量决定。这些结果有助于深入了解没食子酸月桂酯在生物系统中的行为,即膜抗氧化保护和药理活性。

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