Isaka S, Okano T, Sato N, Shimazaki J, Matsuzaki O
Nihon Hinyokika Gakkai Zasshi. 1989 Mar;80(3):402-6. doi: 10.5980/jpnjurol1989.80.402.
From 1979 through 1988, 64 men and 16 women (age range 36-82; mean 63 years) with bladder cancer underwent pelvic lymph node dissection and radical cystectomy with urinary diversion. Bilateral common iliac, external iliac, internal iliac, obturator and presacral nodes were removed and examined. The frequency of involvement of each nodal group was the highest at the common iliac and the external iliac nodes followed by the obturator, presacral and internal iliac nodes. The incidence of lymph node metastasis increased with the tumor grade and pathological stage. The incidence of positive nodes is 3.7% in patients with P1 tumors, 10% in P2, and 17% in P3 tumors. Of these patients, 9 were with nodal metastasis; seven died of metastatic cancer 3 to 37 months post-operatively, two were alive for 4 to 41 months without evidence of recurrence. The mean survival time was significantly longer than that of the historical control group (1975-1978 total cystectomy without node dissection).
从1979年至1988年，64名男性和16名女性（年龄范围36 - 82岁；平均63岁）患有膀胱癌，接受了盆腔淋巴结清扫术和根治性膀胱切除术及尿流改道术。双侧髂总、髂外、髂内、闭孔和骶前淋巴结被切除并进行检查。每个淋巴结组的受累频率在髂总和髂外淋巴结处最高，其次是闭孔、骶前和髂内淋巴结。淋巴结转移的发生率随肿瘤分级和病理分期增加。P1期肿瘤患者的阳性淋巴结发生率为3.7%，P2期为10%，P3期肿瘤为17%。在这些患者中，9例有淋巴结转移；7例在术后3至37个月死于转移性癌症，2例存活4至41个月且无复发迹象。平均生存时间显著长于历史对照组（1975 - 1978年未进行淋巴结清扫的全膀胱切除术）。
