Lin C, Andersen J R, Våge V, Rajalahti T, Mjøs S A, Kvalheim O M
Fjordomics, Førde Hospital Trust, Førde, Norway.
Department of Chemistry, University of Bergen, Bergen, Norway.
Clin Obes. 2016 Aug;6(4):259-67. doi: 10.1111/cob.12151. Epub 2016 Jun 23.
Serum fatty acid (FA) levels were monitored in women with severe obesity during intensive lifestyle intervention. At baseline, total FA levels and most individual FAs were elevated compared to a matching cohort of normal and overweight women (healthy controls). After 3 weeks of intensive lifestyle intervention, total level was only 11-12% higher than in the healthy controls and with almost all FAs being significantly lower than at baseline, but with levels of omega-3 being similar to the healthy controls. This is contrary to observations for patients subjected to bariatric surgery where omega-3 levels dropped to levels significantly lower than in the lifestyle patients and healthy controls. During the next 3 weeks of treatment, the FA levels in lifestyle patients were unchanged, while the weight loss continued at almost the same rate as in the first 3 weeks. Multivariate analysis revealed that weight loss and change of serum FA patterns were unrelated outcomes of the intervention for lifestyle patients. For bariatric patients, these processes were associated probably due to reduced dietary input and increased input from the patients' own fat deposits, causing a higher rate of weight loss and simultaneous reduction of the ratio of serum eicosapentaenoic to arachidonic acid.
在强化生活方式干预期间，对重度肥胖女性的血清脂肪酸（FA）水平进行了监测。在基线时，与匹配的正常和超重女性队列（健康对照）相比，总FA水平和大多数个体FA水平均升高。经过3周的强化生活方式干预后，总水平仅比健康对照高11-12%，几乎所有FA均显著低于基线水平，但ω-3水平与健康对照相似。这与接受减肥手术患者的观察结果相反，在减肥手术患者中，ω-3水平降至显著低于生活方式干预患者和健康对照的水平。在接下来的3周治疗期间，生活方式干预患者的FA水平未发生变化，而体重减轻仍以前3周几乎相同的速度持续。多变量分析显示，体重减轻和血清FA模式变化是生活方式干预患者不相关的结果。对于减肥手术患者，这些过程可能是相关的，这可能是由于饮食摄入减少以及患者自身脂肪储备的贡献增加，导致更高的体重减轻率以及血清二十碳五烯酸与花生四烯酸比例的同时降低。
