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一种当时尚不为人知的病毒——人疱疹病毒6型/7型(HHV-6/7)引发了20世纪70年代的百日咳疫苗争议吗?

Did a then unknown virus, HHV-6/7, give rise to the whooping cough vaccine controversy of the 1970s?

作者信息

Mortimer Philip P

机构信息

Oxford,UK.

出版信息

Epidemiol Infect. 2016 Oct;144(14):2927-2930. doi: 10.1017/S0950268816001060. Epub 2016 Jun 23.

Abstract

During the 1970s there was a gross loss of public confidence in infant diphtheria-tetanus-pertussis (DTP) vaccination in the UK. As well as febrile reactions and convulsions, permanent neurological damage was ascribed to the pertussis component of the vaccine, and those concerns resonated worldwide. The subsequent recognition of human herpes virus 6 (HHV-6) and 7 (HHV-7) as common sources of fever in infancy suggests that they were the main underlying cause of what was reported as DTP constitutional side-effects. With more precise data on the incidence of HHV-6/7 and other virus infections in early life it would be possible to model the concurrence of viral illnesses with routine immunizations. Adventitious viral infections may be the cause of side-effects ascribed to the numerous childhood immunizations now being given.

摘要

20世纪70年代,英国公众对婴幼儿白喉-破伤风-百日咳(DTP)疫苗接种的信心严重丧失。除了发热反应和惊厥外,永久性神经损伤被归因于疫苗中的百日咳成分,这些担忧在全球引起了共鸣。随后,人类疱疹病毒6型(HHV-6)和7型(HHV-7)被确认为婴儿期发热的常见原因,这表明它们是被报告为DTP全身性副作用的主要潜在原因。有了关于生命早期HHV-6/7和其他病毒感染发病率的更精确数据,就有可能模拟病毒疾病与常规免疫接种的同时发生情况。偶然的病毒感染可能是现在众多儿童免疫接种所导致的副作用的原因。

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