Galama J M
Academisch Ziekenhuis, afd. Medische Microbiologie, Nijmegen.
Ned Tijdschr Geneeskd. 1996 Jan 20;140(3):124-8.
A serendipitous discovery during early AIDS investigations was human herpes virus type 6 (HHV-6). Two years later (1988) it was shown that HHV-6 and later on also HHV-7 are the causes of exanthema subitum, a childhood disease with previously unknown causation. HHV-6 and HHV-7 are the main cause of febrile seizures. It is assumed that 90% of children are infected before they are three years old. The viruses are also found in adults; HHV-6 may cause mononucleosis and hepatitis. HHV-6 and HHV-7 infect CD4+ cells and may influence the course of HIV infection. In AIDS patients HHV-6 and cytomegalovirus are often isolated together from the lungs, possibly because they activate each other. Another possibility is that the circumstances in the lungs are favourable to both. HHV-6 and HHV-7 infection may be serologically diagnosed. There is little experience with antiviral treatment.
在早期艾滋病调查期间偶然发现了人类疱疹病毒6型（HHV - 6）。两年后（1988年），研究表明HHV - 6以及后来发现的HHV - 7是幼儿急疹的病因，这是一种此前病因不明的儿童疾病。HHV - 6和HHV - 7是热性惊厥的主要病因。据推测，90%的儿童在三岁前就已感染。在成人中也能发现这些病毒；HHV - 6可能导致单核细胞增多症和肝炎。HHV - 6和HHV - 7感染CD4 +细胞，并可能影响HIV感染的进程。在艾滋病患者中，HHV - 6和巨细胞病毒常从肺部同时分离出来，这可能是因为它们相互激活。另一种可能性是肺部的环境对两者都有利。HHV - 6和HHV - 7感染可以通过血清学进行诊断。抗病毒治疗方面的经验很少。
