Butler Brittany, Sambo Danielle, Khoshbouei Habibeh
University of Florida, Department of Neuroscience and Department of Psychiatry Gainesville, FL 32611.
University of Florida, Department of Neuroscience and Department of Psychiatry Gainesville, FL 32611.
J Chem Neuroanat. 2017 Oct;83-84:41-49. doi: 10.1016/j.jchemneu.2016.06.001. Epub 2016 Jun 19.
Alpha-synuclein is a small, highly charged protein encoded by the synuclein or SNCA gene that is predominantly expressed in central nervous system neurons. Although its physiological function remains enigmatic, alpha-synuclein is implicated in movement disorders such as Parkinson's disease, multiple system atrophy, and in neurodegenerative diseases such as Dementia with Lewy bodies. Here we have focused on reviewing the existing literature pertaining to wild-type alpha-synuclein structure, its properties, and its potential involvement in regulation of dopamine neurotransmission.
α-突触核蛋白是一种由突触核蛋白或SNCA基因编码的小的、高度带电的蛋白质，主要在中枢神经系统神经元中表达。尽管其生理功能仍然不明，但α-突触核蛋白与帕金森病、多系统萎缩等运动障碍以及路易体痴呆等神经退行性疾病有关。在此，我们着重回顾了与野生型α-突触核蛋白结构、其特性以及其在多巴胺神经传递调节中的潜在作用相关的现有文献。
