Hosseini Banafshe, Saedisomeolia Ahmad, Allman-Farinelli Margaret
School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, University of Newcastle, Callaghan, NSW, Australia.
Department of Pharmacy, School of Medicine, Western Sydney University, Richmond, NSW, Australia.
Biol Trace Elem Res. 2017 Feb;175(2):287-297. doi: 10.1007/s12011-016-0785-1. Epub 2016 Jun 22.
The global prevalence of obesity has doubled in recent decades. Compelling evidences indicated that obesity was associated with lower concentrations of specific antioxidants which may play a role in the development of obesity-related diseases such as cardiovascular disease. The present review aimed to synthesize the evidence from studies on the association between obesity and antioxidant micronutrients in a systematic manner. Data bases including MEDLINE, Science Direct, and Cochrane were searched from inception to October 2015. Thirty-one articles were reviewed using the MOOSE checklist. Lower concentrations of antioxidants have been reported in obese individuals among age groups worldwide. Circulatory levels of carotenoids, vitamins E and C, as well as zinc, magnesium, and selenium were inversely correlated with obesity and body fat mass. However, studies demonstrated inconsistencies in findings. Lower status of carotenoids, vitamins E and C, zinc, magnesium, and selenium appears to be associated with adiposity. Intervention studies may be needed to establish the causality of these associations.
近几十年来，全球肥胖患病率翻了一番。有力证据表明，肥胖与特定抗氧化剂浓度降低有关，这些抗氧化剂可能在肥胖相关疾病（如心血管疾病）的发生发展中起作用。本综述旨在系统地综合肥胖与抗氧化剂微量营养素之间关联的研究证据。检索了包括MEDLINE、Science Direct和Cochrane在内的数据库，检索时间从数据库建立至2015年10月。使用MOOSE清单对31篇文章进行了综述。据报道，全球各年龄组肥胖个体的抗氧化剂浓度较低。类胡萝卜素、维生素E和C以及锌、镁和硒的循环水平与肥胖和体脂量呈负相关。然而，研究结果存在不一致之处。类胡萝卜素、维生素E和C、锌、镁和硒水平较低似乎与肥胖有关。可能需要进行干预研究来确定这些关联的因果关系。
