Liu Lin, Ma Song-He, Xia Ling-Jie
a Department of Pain , Henan Province Hospital , Zhengzhou , China.
Neurol Res. 2016 Aug;38(8):717-24. doi: 10.1080/01616412.2016.1188550. Epub 2016 Jun 23.
The thiamin is often used in the treatment of neuropathy, and pregabalin is often used to treat neuropathic pain. Our study examined the influence of thiamin on the efficacy of pregabalin in a rat model of spinal nerve ligation (SNL)-induced neuropathic pain.
Sprague-Dawley male rats were randomly divided into six groups. The neuropathic pain-relieving properties were measured by plantar test, cold plate test, and hot plate test after administration of pregabalin (i.v) and/or thiamin (i.p) in SNL rats 14 days after operation.
In the therapy period, pregabalin, or thiamin alone all produced antinociceptive effects in rats with neuropathic pain. And combination treatment of thiamin and pregabalin resulted in an enhanced pain relief compared to the administration of pregabalin or thiamin alone.
Combination of thiamin and pregabalin produces an additive antinociceptive effect in neuropathic pain rats, this drug combination may offer a beneficial treatment option for neuropathic pain.
硫胺素常用于治疗神经病变，而普瑞巴林常用于治疗神经性疼痛。我们的研究在大鼠脊神经结扎（SNL）诱导的神经性疼痛模型中，检测了硫胺素对普瑞巴林疗效的影响。
将雄性Sprague-Dawley大鼠随机分为六组。术后14天，在SNL大鼠中静脉注射普瑞巴林和/或腹腔注射硫胺素后，通过足底试验、冷板试验和热板试验测量神经性疼痛缓解特性。
在治疗期间，单独使用普瑞巴林或硫胺素均对神经性疼痛大鼠产生了镇痛作用。与单独使用普瑞巴林或硫胺素相比，硫胺素和普瑞巴林联合治疗能增强疼痛缓解效果。
硫胺素和普瑞巴林联合用药对神经性疼痛大鼠产生了相加的镇痛作用，这种药物组合可能为神经性疼痛提供一种有益的治疗选择。
