Alexius B, Engelbrektsson K, Sääf J, Svedberg E, Wetterberg L, Sönnerborg A
Lakartidningen. 1989 May 31;86(22):2108-11.
Forty HIV-1-sero-positive and 15 HIV-1 antibody negative homosexual or bisexual men were examined by means of magnetic resonance imaging (MRI) and 20 neuropsychological tests. Subcortical, mainly frontal cerebral pathological aberrations were detected in 75 per cent of the patients on examination with ultra low field MRI computer assisted classification. No such changes were found among controls. The extent of the subcortical aberrations detected correlated with severity of immune deficiency, stage of infection (CDC classification), duration of infection, and reported neuropsychological symptoms. Neuropsychological testing showed impairment in memory function, concentration capacity, and fine motor control in the patients but not in the controls.
对40名HIV-1血清呈阳性以及15名HIV-1抗体呈阴性的同性恋或双性恋男性进行了磁共振成像（MRI）检查和20项神经心理学测试。通过超低场MRI计算机辅助分类检查发现，75%的患者存在皮质下，主要是额叶的脑病理异常。在对照组中未发现此类变化。检测到的皮质下异常程度与免疫缺陷的严重程度、感染阶段（疾病控制与预防中心分类）、感染持续时间以及报告的神经心理学症状相关。神经心理学测试显示，患者存在记忆功能、注意力集中能力和精细运动控制方面的损害，而对照组则未出现此类损害。
