Matsa Elena, Ahrens John H, Wu Joseph C
Stanford Cardiovascular Institute, Department of Medicine, Division of Cardiology, and Institute of Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, California.
Physiol Rev. 2016 Jul;96(3):1093-126. doi: 10.1152/physrev.00036.2015.
Human induced pluripotent stem cells (hiPSCs) have revolutionized the field of human disease modeling, with an enormous potential to serve as paradigm shifting platforms for preclinical trials, personalized clinical diagnosis, and drug treatment. In this review, we describe how hiPSCs could transition cardiac healthcare away from simple disease diagnosis to prediction and prevention, bridging the gap between basic and clinical research to bring the best science to every patient.
人类诱导多能干细胞（hiPSC）彻底改变了人类疾病建模领域，具有巨大潜力，可作为临床前试验、个性化临床诊断和药物治疗的范式转变平台。在本综述中，我们描述了hiPSC如何能够将心脏医疗从简单的疾病诊断转变为预测和预防，弥合基础研究与临床研究之间的差距，为每位患者带来最佳科学成果。
