Wang Jingjing, Pu Jing, Liu Longding, Che Yanchun, Liao Yun, Wang Lichun, Guo Lei, Feng Min, Liang Yan, Fan Shengtao, Cai Lukui, Zhang Ying, Li Qihan
Institute of Medical Biology, Chinese Academy of Medicine Sciences, Kunming, Yunnan, China.
Glob Pediatr Health. 2016 May 27;3:2333794X16643723. doi: 10.1177/2333794X16643723. eCollection 2016.
Hand, foot, and mouth disease (HFMD), with vesiculae on the hands, feet and mouth, is an infectious disease caused by many viral pathogens. However, the differences of immune response induced by these pathogens are unclear. We compared the clinical manifestations and the levels of immunologic indicators from 60 HFMD patients caused by different viral pathogens to analyze the differences in the immune response. It was shown that Th2 cytokines (IL-4 and IL-10) increased significantly in EV71-infected children; Th1 cytokines (IL-2 and IFN-γ) rose in CA16-infected children; both Th1 and Th2 cytokines elevated in non-EVG-infected children; only individual cytokines (such as IL-10) went up in EVG-infected children. Meanwhile, the antibodies induced by viral infection could not cross-interfere between the different pathogens. These differences might be due to variations in the immune response induced by the individual pathogens or to the pathogenesis of the infections by the individual pathogens.
手足口病（HFMD），其手部、足部和口腔会出现水疱，是一种由多种病毒病原体引起的传染病。然而，这些病原体诱导的免疫反应差异尚不清楚。我们比较了60例由不同病毒病原体引起的手足口病患者的临床表现和免疫指标水平，以分析免疫反应的差异。结果显示，在感染肠道病毒71型（EV71）的儿童中，Th2细胞因子（IL-4和IL-10）显著增加；在感染柯萨奇病毒A16型（CA16）的儿童中，Th1细胞因子（IL-2和IFN-γ）升高；在非肠道病毒通用型（non-EVG）感染的儿童中，Th1和Th2细胞因子均升高；在感染肠道病毒通用型（EVG）的儿童中，仅个别细胞因子（如IL-10）升高。同时，病毒感染诱导产生的抗体在不同病原体之间不会交叉干扰。这些差异可能是由于个体病原体诱导的免疫反应差异，或者是个体病原体感染的发病机制所致。
