Jia Lei, Zhao Cheng-Song, Zhang Li, Li Shuang, Zhang Dai-Tao, Liu Bai-Wei, Wang Quan-Yi, Li Xin-Yu
Beijing Center for Disease Prevention and Control, Beijing 100013, China.
Zhongguo Dang Dai Er Ke Za Zhi. 2011 Aug;13(8):635-7.
To compare the differences of epidemiological and clinical characteristics in children with hand-foot-mouth disease (HFMD) caused by Coxsackievirus A16 (CA16) and Enterovirus 71 (EV71).
The samples of vesicle fluid and throat swabs of 108 children with HFMD were collected and detected for enterovirus by RT-PCR. The clinical data of children with EV71 and CA16 infection were retrospectively reviewed and compared.
The total positive rate of enterovirus was 97.2% (105/108). Of the 105 cases, 56 cases were positive for EV71 (51.9%), 39 cases were positive for CA16 (36.1%), 2 cases were positive for other enterovirus (1.9%), and 8 cases were co-infected by EV71 and CA16 (7.4%). There were no significant differences in age and sex between EV71 and CV16 infected cases. The univariate analysis showed that the incidences of herpes of mouth, erythra of knees, and nose running in children infected by CA16 were higher than in those infected by EV71. The multivariate logistic regression analysis showed that the HFMD children who had erythra of knees had higher probability of CA16 infection.
EV71 should be considered as the pathogen in children with HFMD who have no herpes of mouth, erythra of knees, and nose running.
比较由柯萨奇病毒A16（CA16）和肠道病毒71型（EV71）引起的手足口病（HFMD）患儿的流行病学和临床特征差异。
收集108例手足口病患儿的水疱液和咽拭子样本，采用逆转录聚合酶链反应（RT-PCR）检测肠道病毒。回顾性分析并比较EV71和CA16感染患儿的临床资料。
肠道病毒总阳性率为97.2%（105/108）。105例中，EV71阳性56例（51.9%），CA16阳性39例（36.1%），其他肠道病毒阳性2例（1.9%），EV71和CA16混合感染8例（7.4%）。EV71和CV16感染病例在年龄和性别上无显著差异。单因素分析显示，CA16感染患儿口腔疱疹、膝关节红斑和流涕的发生率高于EV71感染患儿。多因素logistic回归分析显示，膝关节有红斑的手足口病患儿感染CA16的可能性更高。
对于无口腔疱疹、膝关节红斑和流涕的手足口病患儿，应考虑EV71为病原体。
