Jucker M, Meier-Ruge W
Department of Pathology, University of Basel, Medical School, Switzerland.
Microvasc Res. 1989 May;37(3):298-307. doi: 10.1016/0026-2862(89)90048-4.
The intercapillary distance in the parietal cortex (area 39) and hippocampus (CA1 region) was greater in senescent Fischer-344 rats (27 1/2 months old) than in adult Fischer-344 rats (18 months old). Furthermore, an improvement was found in stereological parameter after a 42-day period of treatment with brovincamine (Sabromin) at dosages of 2.5, 5.0, and 10.0 mg/kg. Treated senescent rats showed a dose-dependent decrease in intercapillary distance and an increase in the number of capillary segments per measurement field compared with untreated controls. The values approximated those found in the adult control animals. In the adult rats the administration of the drug induced similar but far less marked changes in the stereology of the capillary network. The findings suggest that brovincamine affects the interactions between nerve cells, astroglia, and capillary blood flow (changes of the intercapillary microenvironment). The results show that a 42-day treatment with brovincamine decreases pericapillary resistance, thus supporting capillary microcirculation.
衰老的Fischer - 344大鼠（27.5月龄）顶叶皮质（39区）和海马（CA1区）的毛细血管间距比成年Fischer - 344大鼠（18月龄）更大。此外，在用剂量为2.5、5.0和10.0mg/kg的溴长春胺（萨溴明）治疗42天后，立体学参数有所改善。与未治疗的对照组相比，接受治疗的衰老大鼠毛细血管间距呈剂量依赖性降低，每个测量视野内的毛细血管段数量增加。这些值接近成年对照动物中的值。在成年大鼠中，药物给药引起毛细血管网络立体学上类似但程度轻得多的变化。这些发现表明，溴长春胺影响神经细胞、星形胶质细胞和毛细血管血流之间的相互作用（毛细血管间微环境的变化）。结果表明，用溴长春胺进行42天治疗可降低毛细血管周围阻力，从而支持毛细血管微循环。
