评估正常血液的屈服应力作为纤维蛋白原浓度和血细胞比容的函数。

Evaluation of the yield stress of normal blood as a function of fibrinogen concentration and hematocrit.

作者信息

Morris C L, Rucknagel D L, Shukla R, Gruppo R A, Smith C M, Blackshear P

机构信息

Department of Hematology/Oncology, Children's Hospital Medical Center, Cincinnati, Ohio 45229-2899.

出版信息

Microvasc Res. 1989 May;37(3):323-38. doi: 10.1016/0026-2862(89)90050-2.

DOI:10.1016/0026-2862(89)90050-2

PMID:2733604

Abstract

The yield stress is a sensitive index of blood fluidity at low shear. Seven healthy adults were studied at hematocrits varying between 40 and 80% and fibrinogen concentrations from 0.0 to 0.935 g/dl. Multivariable analysis was used to determine the functional dependence of yield stress on hematocrit and fibrinogen level. The major findings from this analysis include a decreasing effect of fibrinogen at high concentrations (saturation effect), a relative insensitivity of yield stress to fibrinogen at low concentration (threshold effect), and a strong interaction between the effects of hematocrit and fibrinogen concentration on yield stress. Our results give the normal range of yield stress for a given value of fibrinogen and hematocrit and can be used to predict the effect of reductions in hematocrit or fibrinogen on the yield stress of normal blood.

摘要

屈服应力是低剪切力下血液流动性的一个敏感指标。对7名健康成年人进行了研究，其血细胞比容在40%至80%之间变化，纤维蛋白原浓度在0.0至0.935 g/dl之间。采用多变量分析来确定屈服应力对血细胞比容和纤维蛋白原水平的功能依赖性。该分析的主要发现包括高浓度时纤维蛋白原的降低作用（饱和效应）、低浓度时屈服应力对纤维蛋白原的相对不敏感性（阈值效应），以及血细胞比容和纤维蛋白原浓度对屈服应力的影响之间的强烈相互作用。我们的结果给出了给定纤维蛋白原和血细胞比容值时屈服应力的正常范围，可用于预测血细胞比容或纤维蛋白原降低对正常血液屈服应力的影响。