Isaia G C, Mussetta M, Salamano G
Minerva Endocrinol. 1989 Jan-Mar;14(1):35-40.
In this paper we summarize the main problems connected with the diagnosis of primary osteoporosis, after evidencing the remarkable social importance of the disease, linked to the great increase of aged population; finally the pathogenetic hypotheses more documented are described. From a diagnostic point of view common laboratory investigations are not mostly able to provide sufficient significant informations; recently the dosage of osteocalcin as index of osteoblastic activity and as marker of bone turnover has been suggested. Mainly traditional radiology does not provide sufficient information about the real demineralization rate, while the radiogrammometry can offer sufficiently reliable indications about bone mineral content. Of a greater diagnostic meaning can be considered the bone mineral absorptiometry and in particular the double photonic ray absorptiometry, effected at the level of lumbar spine, that is to say a side earlier affected by the osteoporotic process. With this methodology we are able to obtain precise information about the quantity of the bone mineral content, identifying, at an earlier stage, the patients at risk of osteoporosis.
在本文中，我们在证明了原发性骨质疏松症因其与老年人口大幅增加相关而具有显著社会重要性之后，总结了与该疾病诊断相关的主要问题；最后描述了有更多文献记载的发病机制假说。从诊断角度来看，常见的实验室检查大多无法提供足够有意义的信息；最近有人提出测定骨钙素作为成骨细胞活性指标和骨转换标志物。传统放射学主要无法提供有关实际脱矿速率的充分信息，而放射测量法可以提供关于骨矿物质含量的足够可靠的指标。骨矿物质吸收测定法，尤其是在腰椎水平进行的双光子吸收测定法，具有更大的诊断意义，因为腰椎是骨质疏松过程较早受累的部位。通过这种方法，我们能够获得有关骨矿物质含量的精确信息，在早期识别出有骨质疏松风险的患者。
