Zara C, Perotti F, Ferraro R, Lauri A, Saviotti C, Montrasio M G, Caprotti M, Polatti F
Minerva Endocrinol. 1989 Jan-Mar;14(1):53-6.
The activity of different formulations of synthetic calcitonins on the prevention of bone loss was evaluated in young women after oophorectomy. In the 1st study patients were treated or with salmon calcitonin (CTs) intramuscularly (100 I.U. every second day; 10 patients) either with CTs nasal spray (100 I.U. daily; 10 patients). In the 2nd study patients received or CTs i.m. (100 I.U. every second day; 10 patients) either a synthetic analogue of eel calcitonin (eCT) given i.m. (80 I.U. every 2nd day; 10 patients). All calcitonins formulations were given for 9 months with oral calcium supplement (1 g daily). In the 1st study no significant changes of bone mineral content (BMC) was found at the end of the treatment in both groups. In the 2nd study a statistically significant decrease of BMC was observed in the group treated with eCT while non relevant changes were found in the CTs treated patients. Slight side effects were observed in some patients treated with calcitonin formulations given i.m. Since salmon calcitonin nasal spray was well tolerated and prevented bone loss after oophorectomy its use might be recommended in the treatment of postmenopausal osteoporosis.
在年轻的卵巢切除术后女性中，评估了不同制剂的合成降钙素对预防骨质流失的作用。在第一项研究中，患者分别接受鲑鱼降钙素（CTs）肌肉注射（每两天100国际单位；10名患者）或CTs鼻喷雾剂（每日100国际单位；10名患者）治疗。在第二项研究中，患者分别接受CTs肌肉注射（每两天100国际单位；10名患者）或鳗鱼降钙素（eCT）的合成类似物肌肉注射（每两天80国际单位；10名患者）。所有降钙素制剂均与口服钙剂（每日1克）一起给予9个月。在第一项研究中，两组治疗结束时骨矿物质含量（BMC）均未发现显著变化。在第二项研究中，接受eCT治疗的组中观察到BMC有统计学意义的下降，而接受CTs治疗的患者未发现相关变化。在一些接受肌肉注射降钙素制剂治疗的患者中观察到轻微的副作用。由于鲑鱼降钙素鼻喷雾剂耐受性良好且能预防卵巢切除术后的骨质流失，因此在绝经后骨质疏松症的治疗中可能推荐使用。
